Document Detail

Seizure-freedom with combination therapy in localization-related epilepsy.
MedLine Citation:
PMID:  17913516     Owner:  NLM     Status:  MEDLINE    
We analyzed the effect of combination therapy on seizure frequency in all adult patients (N=193) with focal epilepsy followed at a single institution in a cross-sectional study. One hundred and thirty-five patients were on two AEDs, of them, 37 (27%) were seizure-free, 50 patients were on three AEDs including 5 (10%) seizure-free patients (p<0.01 for seizure-freedom with two AEDs versus three AEDs). Thirty-five different combinations were used in patients on two AEDs and 40 combinations on patients on three drugs emphasizing the difficulties involved in evaluation of the efficacy and tolerability of specific combinations. The significant proportion of seizure-free cases (27%) on duotherapy is suggesting the usefulness of combination therapy in achieving seizure-freedom in epilepsies refractory to single drug treatment. The material in the study was not from a randomized trial and therefore the comparability of patients on different AEDs is uncertain, but on the other hand the clinical practice followed provides a natural experiment suitable for comparative, non-randomized assessment of treatment outcomes.
Jukka Peltola; Maria Peltola; Jani Raitanen; Tapani Keränen; Elham Kharazmi; Anssi Auvinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-29
Journal Detail:
Title:  Seizure     Volume:  17     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-24     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  276-80     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / therapeutic use*
Brain / anatomy & histology*,  physiopathology*
Carbamazepine / analogs & derivatives,  therapeutic use
Drug Therapy, Combination
Frontal Lobe / physiopathology
Fructose / analogs & derivatives,  therapeutic use
Nipecotic Acids / therapeutic use
Occipital Lobe / physiopathology
Parietal Lobe / physiopathology
Piracetam / analogs & derivatives,  therapeutic use
Seizures / diagnosis,  drug therapy*,  physiopathology*
Temporal Lobe / physiopathology
Treatment Outcome
Triazines / therapeutic use
Valproic Acid / therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 0/Nipecotic Acids; 0/Triazines; 0H73WJJ391/topiramate; 230447L0GL/etiracetam; 30237-26-4/Fructose; 33CM23913M/Carbamazepine; 614OI1Z5WI/Valproic Acid; U3H27498KS/lamotrigine; VZI5B1W380/oxcarbazepine; Z80I64HMNP/tiagabine; ZH516LNZ10/Piracetam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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