Document Detail

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.
MedLine Citation:
PMID:  23159379     Owner:  NLM     Status:  Publisher    
While animal models of epilepsy suggest that exogenous cannabinoids may have anticonvulsant properties, scant evidence exists for these compounds' efficacy in humans. Here, we report on two patients whose focal epilepsy was nearly controlled through regular outpatient marijuana use. Both stopped marijuana upon admission to our epilepsy monitoring unit (EMU) and developed a dramatic increase in seizure frequency documented by video-EEG telemetry. These seizures occurred in the absence of other provocative procedures, including changes to anticonvulsant medications. We review these cases and discuss mechanisms for the potentially anticonvulsant properties of cannabis, based on a review of the literature.
Manu Hegde; Carlos Santos-Sanchez; Christopher P Hess; Arif A Kabir; Paul A Garcia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  25     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  563-566     Citation Subset:  -    
Copyright Information:
Published by Elsevier Inc.
Epilepsy Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Epilepsy Center of Excellence, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. Electronic address:
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