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Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep.
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MedLine Citation:
PMID:  12270104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inheritance of the ovulation rate (OR) in the Lacaune meat breed was studied through records from a small nucleus of 36 hyper-prolific ewes screened on farms on the basis of their natural litter size, and from progeny data of three selected Lacaune sires. These sires were chosen at the AI centre according to their breeding values estimated for the mean and the variability of their daughters' litter size. Non-carrier Lacaune dairy ewes were inseminated to produce 121 F1 daughters and 27 F1 sons. Twelve sons (four from each sire) were used in turn to inseminate non-carrier Lacaune dairy ewes providing 260 BC progeny ewes. F1 and BC progeny were brought from private farms and gathered after weaning on an experimental farm where ovulation rates were recorded in the first and second breeding seasons. With an average of 6.5 records each, the mean OR of hyper-prolific ewes was very high (5.34), and 38.4% of records showed a rate of 6 or more. F1 data showed high repeatability of OR (r = 0.54) within ewe, with significant variability among ewes. High OR (> or = 4) were observed in each family. A segregation analysis provided a significant likelihood ratio and classified the three founders as heterozygous. BC ewes also displayed high repeatability of OR (r = 0.47) and the mean OR varied considerably between families (from 1.24 to 1.78). Seven of the 12 BC families presented high-ovulating ewes (at least one record > or = 4) and segregation analysis yielded a highly significant likelihood ratio as compared to an empirical test distribution. The high variability of the mean ovulation rate shown by a small group of daughters of BC ewes inseminated by putative carrier F1 rams, and the very high ovulation rate observed for some of these ewe lambs, confirmed the segregation of a major gene with two co-dominant alleles borne by an autosome. The difference between homozygous non-carriers and heterozygous ewes was about one ovulation on the observed scale and 2.2 standard deviations on the underlying scale.
Authors:
Loys Bodin; Magali SanCristobal; Frédéric Lecerf; Philippe Mulsant; Bernard Bibé; Daniel Lajous; Jean-Pierre Belloc; Francis Eychenne; Yves Amigues; Jean-Michel Elsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics, selection, evolution : GSE     Volume:  34     ISSN:  0999-193X     ISO Abbreviation:  Genet. Sel. Evol.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-09-24     Completed Date:  2002-10-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9114088     Medline TA:  Genet Sel Evol     Country:  France    
Other Details:
Languages:  eng     Pagination:  447-64     Citation Subset:  IM    
Affiliation:
Station d'amélioration génétique des animaux, Institut national de la recherche agronomique, BP 27, 31326 Castanet-Tolosan, France. bodin@toulouse.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding
Crosses, Genetic
DNA / analysis
Female
Fertility
Genes, Dominant
Litter Size / genetics,  physiology
Male
Models, Statistical
Ovulation / genetics*
Pedigree
Selection, Genetic
Sheep / genetics*
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Genet Sel Evol
ISSN: 0999-193X
ISSN: 1297-9686
Publisher: BioMed Central
Article Information
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Copyright © 2002 INRA, EDP Sciences
Received Day: 17 Month: 9 Year: 2001
Accepted Day: 13 Month: 2 Year: 2002
collection publication date: Year: 2002
Electronic publication date: Day: 15 Month: 7 Year: 2002
Volume: 34 Issue: 4
First Page: 447 Last Page: 464
ID: 2705455
Publisher Id: 1297-9686-34-4-447
PubMed Id: 12270104
DOI: 10.1186/1297-9686-34-4-447

Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
Loys Bodin1 Email: bodin@toulouse.inra.fr
Magali SanCristobal2
Frédéric Lecerf2
Philippe Mulsant2
Bernard Bibé3
Daniel Lajous1
Jean-Pierre Belloc4
Francis Eychenne5
Yves Amigues6
Jean-Michel Elsen1
1Station d'amélioration génétique des animaux, Institut national de la recherche agronomique, BP 27, 31326 Castanet-Tolosan, France
2Laboratoire de génétique cellulaire, Institut national de la recherche agronomique, BP 27, 31326 Castanet-Tolosan, France
3Département de génétique animale, Institut national de la recherche agronomique, BP 27, 31326 Castanet-Tolosan, France
4Coopérative OVI-TEST, Route d'Espalion, 12850 Onet-le-Château, France
5Domaine expérimental de Langlade, 31450 Montgiscard, France
6Labogena, Domaine de Vilvert, 78352 Jouy-en-Josas, France

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Article Categories:
  • Research

Keywords: sheep, major gene, ovulation.

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