Document Detail

Segregation of genomes in polyploid tumour cells following mitotic catastrophe.
MedLine Citation:
PMID:  16314119     Owner:  NLM     Status:  MEDLINE    
Following irradiation p53-function-deficient tumour cells undergo mitotic catastrophe and form endopolyploid cells. A small proportion of these segregates nuclei, and give rise to viable descendants. Here we studied this process in five tumour cell lines. After mitotic failure, tumour cells enter the endocycle and form mono-nucleated or multi-nucleated giant cells (MOGC and MNGC). MNGC arise from arrested anaphases, MOGC, from arrested metaphases. In both cases the individual genomes establish a radial pattern by links to a single microtubule organizing centre. Segregation of genomes is also ordered. MNGC present features of mitosis being resumed from late anaphase. In MOGC the sub-nuclei retain arrangement of stacked metaphase plates and are separated by folds of the nuclear envelope. Mitosis then resumes in sub-nuclei directly from metaphase. The data presented indicate that endopolyploid tumour cells preserve the integrity of individual genomes and can potentially re-initiate mitosis from the point at which it was interrupted.
Jekaterina Erenpreisa; M Kalejs; F Ianzini; E A Kosmacek; M A Mackey; D Emzinsh; M S Cragg; A Ivanov; T M Illidge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-11-28
Journal Detail:
Title:  Cell biology international     Volume:  29     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-07     Completed Date:  2006-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1005-11     Citation Subset:  IM    
Biomedicine Centre of the Latvia University, Ratsupites 1, Riga LV-1067, Latvia.
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MeSH Terms
Cell Line, Tumor
Chromosome Segregation*
Hela Cells
Jurkat Cells
Tumor Suppressor Protein p53 / genetics,  physiology
Grant Support
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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