Document Detail


Segregation analysis of serum uric acid in the NHLBI Family Heart Study.
MedLine Citation:
PMID:  10798367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segregation analysis was performed on the serum uric acid measurements from 523 randomly ascertained Caucasian families from the NHLBI Family Heart Study. Gender-specific standardized residuals were used as the phenotypic variable in both familial correlation and segregation analysis. Uric acid residuals were adjusted for age, age2, age3, body mass index (kg/m2), creatinine level, aspirin use (yes/no), total drinks (per week), HOMA insulin resistance index [(glucose * insulin)/22.5], diuretic use (yes/no), and triglyceride level. Sibling correlations (r=0.193) and parent-offspring correlations (r=0.217) were significantly different from zero, but these two familial correlations were not significantly different from one another. After adjustment for covariates, the heritability estimate for serum uric acid was 0.399. Segregation analysis rejected the "no major gene" model but was unable to discriminate between an "environmental" and a "Mendelian major gene" model. These results support the hypothesis that uric acid is a multifactorial trait possibly influenced by more than one major gene, modifying genes, and environmental factors.
Authors:
J B Wilk; L Djousse; I Borecki; L D Atwood; S C Hunt; S S Rich; J H Eckfeldt; D K Arnett; D C Rao; R H Myers
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  106     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-23     Completed Date:  2000-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  355-9     Citation Subset:  IM    
Affiliation:
Boston University School of Medicine, MA 02118, USA. jwilk@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / epidemiology,  genetics
Cohort Studies
Coronary Disease / blood,  epidemiology,  genetics*
European Continental Ancestry Group
Female
Humans
Male
Middle Aged
Models, Genetic
Nuclear Family
Parents
Risk Factors
Statistics as Topic
Uric Acid / blood*
Grant Support
ID/Acronym/Agency:
UO1 HL56563/HL/NHLBI NIH HHS; UO1 HL56564/HL/NHLBI NIH HHS; UO1 HL56565/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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