| Segmental pattern of myocardial sympathetic denervation in idiopathic dilated cardiomyopathy: relationship to regional wall motion and myocardial perfusion abnormalities. | |
| | |
MedLine Citation:
|
PMID: 11845125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Iodine 123-labeled metaiodobenzylguanidine (MIBG) has been used to study cardiac adrenergic nerve activity. Cardiac MIBG uptake is diminished in patients with heart failure. However, it is not known how this reduction is related to regional abnormalities of myocardial wall motion or perfusion. METHODS AND RESULTS: We studied 24 patients with idiopathic dilated cardiomyopathy (ejection fraction <45%) and 15 healthy control subjects using I-123 MIBG cardiac imaging, echocardiographic assessment of wall motion abnormalities, technetium 99m sestamibi perfusion scintigraphy, and hemodynamic assessment. Cardiac MIBG was significantly correlated with ejection fraction (r = 0.67), cardiac index (r = 0.57), left ventricular wall motion score index (r = -0.68), and systolic wall stress (r = -0.61). MIBG was lower in patients than in control subjects (1.43 +/- 0.19 vs 2.05 +/- 0.02; P <.01), whereas the washout rate was higher (P <.01). Moreover, a significant correlation was found between the reduction in MIBG uptake and the severity of echocardiographic wall motion abnormalities in the anterior wall (r = 0.543), apex (r = 0.530), and septum (r = 0.675), as well as with the severity of decrease in resting myocardial perfusion in the anterior wall (r = 0.480) and septum (r = 0.580). CONCLUSIONS: Patients with idiopathic dilated cardiomyopathy show not only global but also regional abnormalities of cardiac sympathetic innervation. The severity of these changes is partially correlated with abnormalities of regional wall motion and myocardial perfusion. |
| | |
Authors:
|
F I Parthenakis; V K Prassopoulos; S I Koukouraki; E A Zacharis; G F Diakakis; N K Karkavitsas; P E Vardas |
Related Documents
:
|
20339495 - Segmental tissue doppler image-derived tei index in patients with regional wall motion ... 8597295 - Morphological changes in the normal pattern of ventricular myoarchitecture in the devel... 18236045 - Mri for the diagnosis of left ventricular apical ballooning syndrome (lvabs). 8111675 - Overestimation of myocardial infarct size on two-dimensional echocardiograms due to rem... 17072705 - The effects of ropivacaine at clinically relevant doses on myocardial ischemia in pigs. 12039485 - Prognostic significance of elevated troponin i after percutaneous coronary intervention. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 9 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 2002 Jan-Feb |
Date Detail:
|
Created Date: 2002-02-14 Completed Date: 2002-03-27 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 15-22 Citation Subset: IM |
Affiliation:
|
Cardiology Department, University Hospital of Heraklion, Crete, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3-Iodobenzylguanidine
/
diagnostic use* Adrenergic Fibers / metabolism Adult Aged Cardiomyopathy, Dilated / physiopathology*, radionuclide imaging Echocardiography Female Heart / innervation*, radionuclide imaging Humans Male Middle Aged Myocardial Contraction / physiology* Presynaptic Terminals Radiopharmaceuticals / diagnostic use* Sympathetic Nervous System / physiology, radionuclide imaging Technetium Tc 99m Sestamibi / diagnostic use* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 77679-27-7/3-Iodobenzylguanidine |
| Comments/Corrections | |
Comment In:
|
J Nucl Cardiol. 2002 Jan-Feb;9(1):127-30
[PMID:
11845138
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose.
Next Document: Risk stratification in patients with remote prior myocardial infarction using rest-stress myocardial...