Document Detail

Segmental pattern of myocardial sympathetic denervation in idiopathic dilated cardiomyopathy: relationship to regional wall motion and myocardial perfusion abnormalities.
MedLine Citation:
PMID:  11845125     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iodine 123-labeled metaiodobenzylguanidine (MIBG) has been used to study cardiac adrenergic nerve activity. Cardiac MIBG uptake is diminished in patients with heart failure. However, it is not known how this reduction is related to regional abnormalities of myocardial wall motion or perfusion. METHODS AND RESULTS: We studied 24 patients with idiopathic dilated cardiomyopathy (ejection fraction <45%) and 15 healthy control subjects using I-123 MIBG cardiac imaging, echocardiographic assessment of wall motion abnormalities, technetium 99m sestamibi perfusion scintigraphy, and hemodynamic assessment. Cardiac MIBG was significantly correlated with ejection fraction (r = 0.67), cardiac index (r = 0.57), left ventricular wall motion score index (r = -0.68), and systolic wall stress (r = -0.61). MIBG was lower in patients than in control subjects (1.43 +/- 0.19 vs 2.05 +/- 0.02; P <.01), whereas the washout rate was higher (P <.01). Moreover, a significant correlation was found between the reduction in MIBG uptake and the severity of echocardiographic wall motion abnormalities in the anterior wall (r = 0.543), apex (r = 0.530), and septum (r = 0.675), as well as with the severity of decrease in resting myocardial perfusion in the anterior wall (r = 0.480) and septum (r = 0.580). CONCLUSIONS: Patients with idiopathic dilated cardiomyopathy show not only global but also regional abnormalities of cardiac sympathetic innervation. The severity of these changes is partially correlated with abnormalities of regional wall motion and myocardial perfusion.
F I Parthenakis; V K Prassopoulos; S I Koukouraki; E A Zacharis; G F Diakakis; N K Karkavitsas; P E Vardas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  9     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Cardiology Department, University Hospital of Heraklion, Crete, Greece.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use*
Adrenergic Fibers / metabolism
Cardiomyopathy, Dilated / physiopathology*,  radionuclide imaging
Heart / innervation*,  radionuclide imaging
Middle Aged
Myocardial Contraction / physiology*
Presynaptic Terminals
Radiopharmaceuticals / diagnostic use*
Sympathetic Nervous System / physiology,  radionuclide imaging
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 77679-27-7/3-Iodobenzylguanidine
Comment In:
J Nucl Cardiol. 2002 Jan-Feb;9(1):127-30   [PMID:  11845138 ]

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