| Segmental mediolytic arteritis--electronmicroscopic and immunohistochemical study. | |
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MedLine Citation:
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PMID: 8307220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined specimens of human gastroepiploic artery aneurysm from a patient having several visceral aneurysms using electronmicroscopic and immunohistochemical techniques. The histopathological and ultrastructural findings confirmed the diagnosis of segmental mediolytic arteritis. Arterial smooth muscle cells from the gastroepiploic artery contained cytoplasmic vacuoles, media was thin and the internal elastic membrane showed distortion. X-ray microanalysis revealed calcium deposits in the medial extracellular space. Antigenic determinants of human immunoglobulins, fibrinogen, complement C3a and factor VIII were demonstrated in the injured artery wall, suggesting that immunocomplexes deposited in the artery wall may be associated with local injury. These findings support the role of autoimmune disorders in the pathogenesis of segmental mediolytic arteritis. |
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Authors:
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T Juvonen; O Räsänen; A Reinilä; S Parkkila; J Nissinen; M I Kairaluoma; R Sormunen; O Niemelä |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of vascular surgery Volume: 8 ISSN: 0950-821X ISO Abbreviation: Eur J Vasc Surg Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-15 Completed Date: 1994-03-15 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709440 Medline TA: Eur J Vasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 70-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Oulu University Hospital and University of Oulu, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aneurysm / complications, pathology Arteries / immunology, pathology Arteritis / complications, immunology, metabolism, pathology* Complement C3 / analysis Factor VIII / analysis Female Fibrinogen / analysis Fluorescent Antibody Technique Humans Immunoglobulins / analysis Male Muscle, Smooth, Vascular / pathology, ultrastructure Stomach / blood supply Tunica Intima / chemistry, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Immunoglobulins; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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