Document Detail


Segmental cell kinetics of the human anagen hair: a DNA-flow cytometric analysis.
MedLine Citation:
PMID:  2313118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell kinetics of anagen scalp hair taken by punch biopsies from 70 healthy male volunteers were determined at nine different defined bulbar and follicular hair segments using microdissection and DNA-flow cytometry. The highest mean proliferative activity (S-phase) was measured within the lowermost bulbar segment (14.0%), but decreased to 7.6% at Auber's segment and to 5.9% at the follicle isthmus. Notably, the S-phase data of the upper follicular segments (subdermal 2.4%, infundibular 2.4%) were found to be similar to those of the epidermis (2.5%). This study supporting and supplementing former autoradiographic investigations on human hair matrix epithelium clearly demonstrates the main proliferative activity of the anagen hair follicle being localized in the bulbar segments below Auber's level. Moreover, the method described is well suited for studying the effects of agents influencing cell growth (e.g., hormones or drugs) on the cell kinetics of different anagen hair compartments.
Authors:
F Kiesewetter; H Schell; C Seidel; A Arai; O P Hornstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  94     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-23     Completed Date:  1990-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Erlangen-Nürnberg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Cycle
DNA / analysis
Flow Cytometry / methods
Hair / cytology*
Humans
Interphase
Kinetics
Male
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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