Document Detail


Segmental cable modelling of electrotonic transfer properties of deep superior colliculus neurons in the cat.
MedLine Citation:
PMID:  3033065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A segmental cable model of tecto-reticulo-spinal neurons of cat superior colliculus was constructed, based on detailed anatomical measurements from three neurons. The calculated membrane resistance for which the model best fitted the measured input resistance was 2,300-3,000 omega cm2. Electrotonic length of dendrites fell under 0.59-1.20 and 0.52-1.05 length constants, while the mean electrotonic length for the three cells averaged 0.91, 0.79, 0.81 and 0.80, 0.70, 0.71 (for sealed-end and open-end cable termination, respectively). Dendrite-to-soma conductance ratios averaged 16.0, 10.7, 7.5 and 21.3, 14.1, 11.4 for the two different end conditions, respectively. Synaptic efficacy was estimated by the transfer of steady-state voltage or current reaching the soma from distal dendritic locations. While voltage transfer was less than 1%, almost 60% of injected current (or charge) reached the soma. Analysis of voltage transients recorded experimentally in TRSNs demonstrated considerable difference between parameters derived from either equivalent-cylinder model or segmental cable model. The obvious deviations of TRSNs both in anatomical and electrotonic respect from the assumptions of the equivalent-cylinder model indicate that the detailed cable model will give a more appropriate description of these neurons. The significance of the estimated electrotonic parameters for the particular burst generation mechanism of TRSNs is discussed.
Authors:
A Schierwagen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal für Hirnforschung     Volume:  27     ISSN:  0021-8359     ISO Abbreviation:  J Hirnforsch     Publication Date:  1986  
Date Detail:
Created Date:  1987-06-09     Completed Date:  1987-06-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421521     Medline TA:  J Hirnforsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  679-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Dendrites / physiology*
Electric Conductivity
Membrane Potentials
Models, Neurological
Neurons / physiology
Superior Colliculi / physiology*
Synapses / physiology
Synaptic Transmission*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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