| Segmental analgesic effect and reduction of halothane MAC from epidural fentanyl in humans. | |
| | |
MedLine Citation:
|
PMID: 1595918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To clarify the site of action of epidural fentanyl, we compared the effects of epidural and intravenous fentanyl on the change in pressure pain threshold (PPT) and the minimum alveolar concentration (MAC) of halothane. Seventy patients who underwent gastrectomy in the PPT study group and 84 female patients who underwent hysterectomy in the MAC study group were assigned randomly to seven groups in each study. The seven groups each received a bolus injection of 1, 2, or 4 micrograms/kg of fentanyl, either intravenously or epidurally, and of saline solution epidurally. Compared with intravenous fentanyl, epidural fentanyl significantly increased (P less than 0.01) PPT around surgical incisions by approximately 50%, 100%, and 150% of preadministration levels 1 h after administration of 1, 2, and 4 micrograms/kg, respectively, and significantly reduced (P less than 0.05) halothane MAC at the same doses. These data suggest that the more potent analgesic and anesthetic effects of epidural fentanyl, compared with intravenous fentanyl, are due mainly to the segmental analgesia produced by its spinal analgesic action. |
| | |
Authors:
|
Y Inagaki; T Mashimo; I Yoshiya |
Related Documents
:
|
9773148 - High thoracic/low cervical, long-term intrathecal (i.t.) infusion of bupivacaine allevi... 10195518 - Evaluating t-wave amplitude as a guide for detecting intravascular injection of a test ... 7201268 - Epidural meperidine-bupivacaine for obstetric analgesia. 12518878 - Analgesic and systemic effects of ketamine, xylazine, and lidocaine after subarachnoid ... 7712008 - Significance of nitric oxide in the stimulation of intestinal fluid absorption in the r... 150598 - An in vitro study of how much methylprednisolone is needed to produce immunosuppression. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 74 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1992 Jun |
Date Detail:
|
Created Date: 1992-06-26 Completed Date: 1992-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 856-64 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology, Osaka University Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Analgesia Anesthesia, Epidural Drug Interactions Female Fentanyl* / administration & dosage, pharmacology Halothane / pharmacokinetics* Humans Injections, Epidural Injections, Intravenous Male Middle Aged Pain / drug therapy, physiopathology Pain Measurement / drug effects Prospective Studies Pulmonary Alveoli / metabolism Sensory Thresholds / drug effects |
| Chemical | |
Reg. No./Substance:
|
151-67-7/Halothane; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nimodipine reduces the toxicity of intravenous bupivacaine in rats.
Next Document: Phenylephrine does not limit myocardial blood flow or oxygen delivery during isoflurane-induced hypo...