Document Detail


Segmental differences of impaired diastolic relaxation following cardiopulmonary bypass surgery in children: a tissue Doppler study.
MedLine Citation:
PMID:  19821817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired myocardial relaxation is an important aftereffect of cardiopulmonary bypass (CPB). Infants with their immature calcium metabolism may be particularly vulnerable. However, it has been difficult to quantitate diastolic dysfunction clinically. This study used tissue Doppler to measure regional diastolic myocardial velocities in 31 pediatric patients undergoing open heart surgery. Color tissue Doppler images were acquired in the operating room before and 8 and 24 h post CPB surgery. Early (E) and atrial (A) diastolic velocities were determined. Long axis motion was assessed from apical views near the mitral and tricuspid rings and radial wall motion from the parasternal view. The study included 31 children aged 3.6 +/- 4.4 years (6 days to 16 years), with a mean weight of 14.7 +/- 13.7 kg and body surface area of 0.59 +/- 0.35 m(2). Tissue Doppler analysis of regional wall motion revealed abnormal left ventricle (LV) and right ventricle (RV) diastolic relaxation in the early postoperative phase after CPB. Initially, all segments were significantly altered, but by 24 h, regional differences became apparent: LV radial wall motion was recovered, while longitudinal fibers in LV and RV appeared to be less resilient. RV myocardial mechanics were most abnormal. Tissue Doppler analysis may deepen our understanding of myocardial recovery and offers a sensitive tool to compare different cardioprotective strategies.
Authors:
Linda B Pauliks; Akif Undar; J Brian Clark; John L Myers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-11
Journal Detail:
Title:  Artificial organs     Volume:  33     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  904-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Penn State College of Medicine, Penn State Children's Hospital, Hershey, PA 17033, USA. lpauliks@hmc.psu.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cardiopulmonary Bypass*
Child
Child, Preschool
Diastole*
Echocardiography, Doppler*
Female
Heart Ventricles / pathology,  physiopathology
Humans
Infant
Infant, Newborn
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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