Document Detail


Segment and cell type lineage restrictions during pharyngeal arch development in the zebrafish embryo.
MedLine Citation:
PMID:  8162849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In zebrafish, the segmental series of pharyngeal arches is formed predominantly by two migratory cell types, neural crest and paraxial mesoderm, which arise in the early embryo. Neural crest cells migrate ventrally out of the neuroepithelium and into the arches to form cartilage, neurons, glia and pigment cells. Surrounding mesoderm generates muscles and endothelia. We labeled individual pharyngeal precursor cells with fluorescent dyes and found that their clonal progeny were confined to single segments and generated single cell types. When a neural crest or mesodermal cell was marked before migration into the pharynx, its progeny dispersed but generally remained confined to a single arch primordium. Such segmental restrictions arose first in the most rostral arches, mandibular and hyoid, and progressed caudally. The phenotypes of progeny generated by single cells were examined in the mandibular arch. Clones derived from premigratory neural crest cells generally did not contribute to more than one cell type. Further, the progenitors of some cell types were spatially separated in the premigratory crest. In particular, neurogenic crest cells were situated further laterally than cells that generate cartilage and connective tissues, while pigment and glial cell progenitors were more evenly distributed. Based on these results we suggest that arch precursors may be specified as to their eventual fates before the major morphogenetic movements that form the arch primordia. Further, cell movements are restricted during segmentation establishing a group of arch precursors as a unit of developmental patterning, as in the fashion of vertebrate rhombomeres or segmental lineage compartments in Drosophila.
Authors:
T F Schilling; C B Kimmel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  120     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-94     Citation Subset:  IM    
Affiliation:
Institute of Neuroscience, University of Oregon, Eugene 97403.
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MeSH Terms
Descriptor/Qualifier:
Animals
Branchial Region / embryology*
Cell Movement / physiology
Mesoderm / cytology,  physiology*
Microscopy, Fluorescence
Morphogenesis / physiology
Neural Crest / cytology,  physiology*
Zebrafish / embryology*
Grant Support
ID/Acronym/Agency:
5T32 HD07348/HD/NICHD NIH HHS; HD22486/HD/NICHD NIH HHS; NS17963/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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