Document Detail

Seeking a regulatory roadmap for heart morphogenesis.
MedLine Citation:
PMID:  10355034     Owner:  NLM     Status:  MEDLINE    
Despite descriptive studies spanning centuries, we are still lacking an integrated concept of how molecular patterning information is developed in the heart, and how this information guides morphogenesis. With an increasing number of regionally-expressed cardiac genes and transgenes being identified, along with new animal models of cardiac dysmorphogenesis and an exciting array of genetic tools for further dissection, the need for an integrated morphogenetic concept is acute. Models invoking a linear array of cardiac segments are difficult to reconcile with the observation that those segments are evident only on the outer curvature of the heart tube. Molecular and anatomical evidence supports the view that chamber specification is achieved by interpretation of dorso-ventral (inner curvature/outer curvature), as well as anterior-posterior patterning information in the primary heart tube. In this essay, I examine some of the issues influencing and perhaps confusing our view of cardiac morphogenesis and briefly discuss regulatory genes in the context of an evolving morphogenetic model.
R P Harvey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  10     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-07-22     Completed Date:  1999-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Victor Chang Cardiac Research Institute, St. Vincent's Hospital, Darlinghurst, Australia.
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MeSH Terms
Basic Helix-Loop-Helix Transcription Factors
DNA-Binding Proteins / biosynthesis
Embryonic and Fetal Development
Gene Expression Regulation, Developmental / physiology
Heart / embryology*,  physiology
Homeodomain Proteins / biosynthesis
MADS Domain Proteins
Morphogenesis / physiology
Myocardium / metabolism
Myogenic Regulatory Factors / biosynthesis
Transcription Factors / biosynthesis
Xenopus Proteins*
Zebrafish Proteins
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/HAND2 protein, human; 0/Hand1 protein, mouse; 0/Hand2 protein, mouse; 0/Homeodomain Proteins; 0/MADS Domain Proteins; 0/MEF2C protein, human; 0/Mef2c protein, mouse; 0/Myogenic Regulatory Factors; 0/NKX2-5 protein, human; 0/Nkx2-5 protein, mouse; 0/Transcription Factors; 0/Xenopus Proteins; 0/Zebrafish Proteins; 0/hand2 protein, zebrafish; 0/helix-loop-helix protein, eHAND; 0/myocyte-specific enhancer-binding factor 2

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