| Seeking a regulatory roadmap for heart morphogenesis. | |
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MedLine Citation:
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PMID: 10355034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite descriptive studies spanning centuries, we are still lacking an integrated concept of how molecular patterning information is developed in the heart, and how this information guides morphogenesis. With an increasing number of regionally-expressed cardiac genes and transgenes being identified, along with new animal models of cardiac dysmorphogenesis and an exciting array of genetic tools for further dissection, the need for an integrated morphogenetic concept is acute. Models invoking a linear array of cardiac segments are difficult to reconcile with the observation that those segments are evident only on the outer curvature of the heart tube. Molecular and anatomical evidence supports the view that chamber specification is achieved by interpretation of dorso-ventral (inner curvature/outer curvature), as well as anterior-posterior patterning information in the primary heart tube. In this essay, I examine some of the issues influencing and perhaps confusing our view of cardiac morphogenesis and briefly discuss regulatory genes in the context of an evolving morphogenetic model. |
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Authors:
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R P Harvey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in cell & developmental biology Volume: 10 ISSN: 1084-9521 ISO Abbreviation: Semin. Cell Dev. Biol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-07-22 Completed Date: 1999-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9607332 Medline TA: Semin Cell Dev Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 99-107 Citation Subset: IM |
Affiliation:
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Victor Chang Cardiac Research Institute, St. Vincent's Hospital, Darlinghurst, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins / biosynthesis Embryonic and Fetal Development Gene Expression Regulation, Developmental / physiology Heart / embryology*, physiology Homeodomain Proteins / biosynthesis Humans MADS Domain Proteins Mice Morphogenesis / physiology Myocardium / metabolism Myogenic Regulatory Factors / biosynthesis Transcription Factors / biosynthesis Xenopus Proteins* Zebrafish Proteins |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/HAND2 protein, human; 0/Hand1 protein, mouse; 0/Hand2 protein, mouse; 0/Homeodomain Proteins; 0/MADS Domain Proteins; 0/MEF2C protein, human; 0/Mef2c protein, mouse; 0/Myogenic Regulatory Factors; 0/NKX2-5 protein, human; 0/Nkx2-5 protein, mouse; 0/Transcription Factors; 0/Xenopus Proteins; 0/Zebrafish Proteins; 0/hand2 protein, zebrafish; 0/helix-loop-helix protein, eHAND; 0/myocyte-specific enhancer-binding factor 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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