Document Detail


Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development.
MedLine Citation:
PMID:  20824512     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We develop a family of branching process models to study cerebral cortical development at the level of individual neural stem and progenitor cells (NS/PCs) and the neurons they produce. Population-level data about "the average NS/PC" is incorporated as constraints for exploring (i) heterogeneity in the proliferative neural cell types and (ii) variability in daughter cell fate decision making. Preliminary studies demonstrate this variability, generate testable hypotheses about heterogeneity, and motivate new experiments moving forward.
Authors:
Hugh R Macmillan; Michael J McConnell
Publication Detail:
Type:  Journal Article     Date:  2010-09-08
Journal Detail:
Title:  Theory in biosciences = Theorie in den Biowissenschaften     Volume:  130     ISSN:  1611-7530     ISO Abbreviation:  Theory Biosci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708216     Medline TA:  Theory Biosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  31-43     Citation Subset:  IM    
Affiliation:
Department of Mathematical Sciences, Clemson University, Clemson, SC, 29634-0975,  USA, hughrobertmacmillan@gmail.com.
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