| Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled. | |
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MedLine Citation:
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PMID: 3496419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seeding of distinct intrathymic microenvironments defined by direct thymocyte-stromal cell interactions was correlated with T cell development in situ using radiation and nonradiation chimeras of Thy-1.1/1.2 congenic mice. The results identify associations of thymocytes with I-A- macrophages in the cortex as the earliest discernible cell-cell interactions during thymopoiesis. After a significant delay, this recognition stage is followed by concomitant interactions of T cells with I-A+ epithelial cells in the cortex and bone marrow-derived I-A+ dendritic cells in the medulla. All three types of T cell-stromal cell interactions occur after seeding of the intrathymic precursor cell subset and before development of mature medullary-type T cells. The seeding kinetics imply that recognition of cortical epithelial cells by thymocytes in situ represents a relatively late stage of cortical T cell development, whereas thymocyte-dendritic cell interactions denote a very early stage of T cell development in the medulla. The relative positioning of these cell-cell recognition stages during the course of T cell maturation pertains to a putative role of these microenvironments in selection and tolerization of the T cell repertoire. |
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Authors:
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B A Kyewski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 166 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-08-26 Completed Date: 1987-08-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 520-38 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication* Cell Differentiation Clone Cells Mice Mice, Inbred C57BL Radiation Chimera T-Lymphocytes / cytology* Thymus Gland / cytology* |
| Grant Support | |
ID/Acronym/Agency:
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CA-03352/CA/NCI NIH HHS; CA-10372/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 8 Year: 1987 Volume: 166 Issue: 2 First Page: 520 Last Page: 538 ID: 2189581 Publisher Id: 87252945 PubMed Id: 3496419 |
| Seeding of thymic microenvironments defined by distinct thymocyte- stromal cell interactions is developmentally controlled | |
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