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Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.
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MedLine Citation:
PMID:  3496419     Owner:  NLM     Status:  MEDLINE    
Seeding of distinct intrathymic microenvironments defined by direct thymocyte-stromal cell interactions was correlated with T cell development in situ using radiation and nonradiation chimeras of Thy-1.1/1.2 congenic mice. The results identify associations of thymocytes with I-A- macrophages in the cortex as the earliest discernible cell-cell interactions during thymopoiesis. After a significant delay, this recognition stage is followed by concomitant interactions of T cells with I-A+ epithelial cells in the cortex and bone marrow-derived I-A+ dendritic cells in the medulla. All three types of T cell-stromal cell interactions occur after seeding of the intrathymic precursor cell subset and before development of mature medullary-type T cells. The seeding kinetics imply that recognition of cortical epithelial cells by thymocytes in situ represents a relatively late stage of cortical T cell development, whereas thymocyte-dendritic cell interactions denote a very early stage of T cell development in the medulla. The relative positioning of these cell-cell recognition stages during the course of T cell maturation pertains to a putative role of these microenvironments in selection and tolerization of the T cell repertoire.
B A Kyewski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  166     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-26     Completed Date:  1987-08-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  520-38     Citation Subset:  IM    
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MeSH Terms
Cell Communication*
Cell Differentiation
Clone Cells
Mice, Inbred C57BL
Radiation Chimera
T-Lymphocytes / cytology*
Thymus Gland / cytology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 8 Year: 1987
Volume: 166 Issue: 2
First Page: 520 Last Page: 538
ID: 2189581
Publisher Id: 87252945
PubMed Id: 3496419

Seeding of thymic microenvironments defined by distinct thymocyte- stromal cell interactions is developmentally controlled

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