| Seeding human arterial prostheses with mechanically derived endothelium. The detrimental effect of smoking. | |
| | |
MedLine Citation:
|
PMID: 6237209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endothelial healing of Dacron arterial prostheses can be hastened in dogs by seeding autogenous venous endothelium onto the prostheses in a single-staged operation. To determine whether this technique enhances the patency of human grafts, we studied the results of 186 operations on 161 patients performed between February 23, 1978, and December 1, 1982. Alternately allocating patients to treatment with seeded and unseeded Dacron knitted prostheses, we performed axillary-femoral and axillary-femoral-femoral bypasses in 11 patients (six seeded and five unseeded) and femoral-femoral bypasses in 28 (13 seeded and 15 unseeded). By a randomized block method of treatment allocation, femoral-popliteal grafts were installed in 147 limbs (112 vein, 18 seeded, and 17 unseeded). Patency was analyzed by the life-table method. Overall, femoral-femoral and femoral-popliteal bypasses demonstrated no difference between the seeded and unseeded grafts. Patency was somewhat better in seeded than unseeded axillary-femoral bypasses. Nevertheless, nonsmokers with seeded femoral-popliteal Dacron grafts enjoyed a significantly better graft patency than those with unseeded grafts (p = 0.035), whereas a substantial deterioration of seeded Dacron grafts was observed in those patients who smoked (p = 0.008 at 6 months). Vein grafts performed better than either seeded or unseeded Dacron prostheses (p = 0.016). Serum beta-thromboglobulin (BTG) levels varied widely and did not differ among any of the treatment groups. We concluded that endothelial seeding improved the patency of human arterial prostheses but that results were worse if the patient was a smoker. BTG was not a useful measure of the platelet activation induced by an arterial prosthesis. |
| | |
Authors:
|
M Herring; A Gardner; J Glover |
Related Documents
:
|
16454989 - Reoperations for occluded arterial bypasses in the lower limbs. 9333089 - Femoral artery occlusion in cavalier king charles spaniels. 21631219 - Decompressive hemicraniectomy after malignant middle cerebral artery infarction: ration... 6497629 - The need for arteriography in diabetic patients with gangrene and palpable foot pulses. 17560609 - Hemorrhagic shock in the rat: comparison of carotid and femoral cannulation. 3703689 - Venous blood flow in the leg after ligation of the femoral vein during cardiac catheter... 21364249 - Ruptured-plaque-like appearance of restenotic tissue following sirolimus-eluting stent ... 22428499 - Left atrial myxoma with coronary artery disease: an unexpected preoperative finding--ca... 15923119 - Comparison of influence of esophageal carcinoma operations on pulmonary function. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of vascular surgery Volume: 1 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1984 Mar |
Date Detail:
|
Created Date: 1984-11-16 Completed Date: 1984-11-16 Revised Date: 2012-10-03 |
Medline Journal Info:
|
Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 279-89 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Coagulation Disorders
/
prevention & control Blood Vessel Prosthesis* Endothelium* Femoral Artery Graft Occlusion, Vascular Heparin / therapeutic use Humans Polyethylene Terephthalates Popliteal Artery Saphenous Vein / transplantation Smoking* Transplantation, Autologous Wound Healing |
| Chemical | |
Reg. No./Substance:
|
0/Polyethylene Terephthalates; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fetal cardiac dimensions: a potential tool for the diagnosis of congenital heart defects.
Next Document: Simple methods for direct antibiotic protection of synthetic vascular grafts.