Document Detail


Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.
MedLine Citation:
PMID:  12164273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus. The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents. Goodyerin exhibited a significant and dose-dependent sedative and anticonvulsant effect.
Authors:
Xiao-Ming Du; Ning-Yi Sun; Nanako Takizawa; Yong-Tian Guo; Yukihiro Shoyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  16     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-08-07     Completed Date:  2003-01-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Affiliation:
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology,  therapeutic use*
Convulsants / pharmacology
Disaccharides / isolation & purification,  pharmacology,  therapeutic use*
Flavonoids / isolation & purification,  pharmacology,  therapeutic use*
Flavonols
Glycosides / pharmacology,  therapeutic use
Hypnotics and Sedatives / pharmacology,  therapeutic use*
Male
Mice
Mice, Inbred ICR
Motor Activity / drug effects
Orchidaceae*
Pentobarbital / pharmacology
Phytotherapy*
Picrotoxin / pharmacology
Plant Extracts / pharmacology,  therapeutic use*
Rats
Rats, Sprague-Dawley
Seizures / chemically induced,  drug therapy
Sleep Disorders / chemically induced,  drug therapy
Chemical
Reg. No./Substance:
0/3-((6-O-(6-deoxymannopyranosyl)glucopyranosyl)oxy)-5,7-dihydroxy-8-((4-hydroxy-3,5-dimethoxyphenyl)methyl)-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; 0/Anticonvulsants; 0/Convulsants; 0/Disaccharides; 0/Flavonoids; 0/Flavonols; 0/Glycosides; 0/Hypnotics and Sedatives; 0/Plant Extracts; 124-87-8/Picrotoxin; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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