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Sedation in traumatic brain injury.
MedLine Citation:
PMID:  23050154     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Several different classes of sedative agents are used in the management of patients with traumatic brain injury (TBI). These agents are used at induction of anaesthesia, to maintain sedation, to reduce elevated intracranial pressure, to terminate seizure activity and facilitate ventilation. The intent of their use is to prevent secondary brain injury by facilitating and optimising ventilation, reducing cerebral metabolic rate and reducing intracranial pressure. There is limited evidence available as to the best choice of sedative agents in TBI, with each agent having specific advantages and disadvantages. This review discusses these agents and offers evidence-based guidance as to the appropriate context in which each agent may be used. Propofol, benzodiazepines, narcotics, barbiturates, etomidate, ketamine, and dexmedetomidine are reviewed and compared.
Authors:
Oliver Flower; Simon Hellings
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Publication Detail:
Type:  Journal Article     Date:  2012-09-20
Journal Detail:
Title:  Emergency medicine international     Volume:  2012     ISSN:  2090-2859     ISO Abbreviation:  Emerg Med Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-10-11     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101567070     Medline TA:  Emerg Med Int     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  637171     Citation Subset:  -    
Affiliation:
University of Sydney, Sydney, NSW, Australia ; Department of Intensive Care, Royal North Shore Hospital, Sydney, NSW 2065, Australia.
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