Document Detail

Sedation administered to very low birth weight premature infants.
MedLine Citation:
PMID:  9134507     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to evaluate the impact of individualized developmental care for very low birth weight infants on the amount of sedation used in their treatment. STUDY DESIGN: A randomized control trial was conducted. Each infant in the experimental group underwent evaluation weekly, and individualized behaviorally oriented care plans, aimed at reducing stress and promoting self-regulatory behaviors, were prepared and implemented. Control infants received the usual standard of nursery care. Total doses of opioids and chloral hydrate were calculated. Severity of illness during the initial hospital stay was stratified with use of the Neonatal Medical Index. RESULTS: Severely ill infants in the treatment group required less chloral hydrate than those in the control group. Infants who were not severely ill received little or no sedation, and among this subgroup treatment and control infants did not differ. CONCLUSIONS: We speculate that developmentally based care reduces stress levels in severely ill very low birth weight infants and thus decreases sedation requirements.
C Heller; J C Constantinou; K VandenBerg; W Benitz; B E Fleisher
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  17     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-07-16     Completed Date:  1997-07-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM    
Department of Pediatrics, Stanford University School of Medicine, CA 94305-5119, USA.
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MeSH Terms
Chloral Hydrate / administration & dosage*
Conscious Sedation*
Hypnotics and Sedatives / administration & dosage*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight*
Intensive Care Units, Neonatal
Narcotics / administration & dosage*
Stress, Physiological / prevention & control*
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Narcotics; 302-17-0/Chloral Hydrate
Comment In:
J Perinatol. 1999 Jan;19(1):80-1   [PMID:  10685210 ]

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