Document Detail


Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis.
MedLine Citation:
PMID:  18052029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three new Securinega alkaloids, secu'amamines B-D ( 1- 3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues ( 4, 6- 9). The structures 1- 3 were elucidated by spectroscopic methods including 2D NMR, and all eight compounds were evaluated for cytotoxicity against two cancer cell lines.
Authors:
Ayumi Ohsaki; Yukino Kobayashi; Kaisuke Yoneda; Akio Kishida; Haruaki Ishiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-01
Journal Detail:
Title:  Journal of natural products     Volume:  70     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2003-5     Citation Subset:  IM    
Affiliation:
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan. a-ohsaki.fm@tmd.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / chemistry,  isolation & purification*,  pharmacology*
Animals
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Euphorbiaceae / chemistry*
Heterocyclic Compounds, Bridged-Ring / chemistry,  isolation & purification*,  pharmacology*
Humans
Japan
Mice
Molecular Conformation
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Wood / chemistry
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Antineoplastic Agents, Phytogenic; 0/Heterocyclic Compounds, Bridged-Ring; 0/secu'amamine B; 0/secu'amamine C; 0/secu'amamine D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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