Document Detail

Secular trends and geographical variations in the dietary intake of polybrominated diphenyl ethers (PBDEs) using archived samples from the early 1980s and mid 1990s in Japan.
MedLine Citation:
PMID:  15953845     Owner:  NLM     Status:  MEDLINE    
A retrospective exposure assessment among the general population for polybrominated diphenyl ethers (PBDEs) was conducted using dietary surveys. We analyzed samples of food duplicate portions collected in the early 1980s (1980 survey: N=40) and the mid 1990s (1995 survey: N=39) from female subjects (5 participants from each of 8 sites per survey except for one site) living throughout Japan, from the north (Hokkaido) to the south (Okinawa). The study populations in the 1980 and 1995 surveys were different, but lived in the same communities. We measured four PBDE congeners [2,2',4,4'-tetrabrominated diphenyl ether (tetraBDE): #47; 2,2',4,4',5-pentaBDE: #99; 2,2',4,4',6-pentaBDE: #100; and 2,2',4,4',5,5'-hexaBDE: #153] in the diet. #99 was the most abundant congener in the diet (49% of the total PBDEs), followed by #47 (33%), #100 (12%) and #153 (6%). Regional variations found in the 1980 survey decreased in the 1995 survey. The total daily intake of PBDEs (ng/d) [GM (GSD)] in the 1980 survey [91.4 (4.1)] was not significantly different from that in the 1995 survey [93.8 (3.4)] for the total population, nor did it differ among the sites including Shimane, in which a 20-fold increase in serum concentrations was observed in the same population1). In consideration of the significant increases in the serum concentration, inhalation may be more important than food ingestion as the route of human exposure to PBDEs.
Yasuhiko Wada; Akio Koizumi; Takeo Yoshinaga; Kouji Harada; Kayoko Inoue; Akiko Morikawa; Junko Muroi; Sumiko Inoue; Bita Eslami; Iwao Hirosawa; Akitsu Hirosawa; Shigeo Fujii; Yoshinori Fujimine; Noriyuki Hachiya; Shigeki Koda; Yukinori Kusaka; Katsuyuki Murata; Haruo Nakatsuka; Kazuyuki Omae; Norimitsu Saito; Shinichiro Shimbo; Katsunobu Takenaka; Tatsuya Takeshita; Hidemi Todoriki; Takao Watanabe; Masayuki Ikeda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational health     Volume:  47     ISSN:  1341-9145     ISO Abbreviation:  J Occup Health     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Hyogo College of Medicine, Japan.
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MeSH Terms
Data Collection
Environmental Exposure*
Middle Aged
Polybrominated Biphenyls / analysis*
Retrospective Studies
Reg. No./Substance:
0/Ethers; 0/Polybrominated Biphenyls

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