| Secrets of aging: What does a normally aging brain look like? | |
| | |
MedLine Citation:
|
PMID: 22003369 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Over the past half century, remarkable progress has been made in understanding the biological basis of memory and how it changes over the lifespan. An important conceptual advance during this period was the realization that normative cognitive trajectories can exist independently of dementing illness. In fact, mammals as different as rats and monkeys, who do not spontaneously develop Alzheimer's disease, show memory impairments at advanced ages in similar domains as those observed in older humans. Thus, animal models have been particularly helpful in revealing brain mechanisms responsible for the cognitive changes that occur in aging. During these past decades, a number of empirical and technical advances enabled the discoveries that began to link age-related changes in brain function to behavior. The pace of innovation continues to accelerate today, resulting in an expanded window through which the secrets of the aging brain are being deciphered. |
| | |
Authors:
|
Carol A Barnes |
Related Documents
:
|
21925769 - Mitochondrial dna deletions cause the biochemical defect observed in alzheimer's disease. 7701089 - Assessment of cognitive decline associated with aging: a comparison of individuals with... 22120149 - Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the ... 12470689 - Relations between aging sensory/sensorimotor and cognitive functions. 20398119 - Serum lipid levels and cognitive change in late life. 9302789 - Case-finding incontinence in the over-75s. 3391519 - The epidemiology of gallstone disease in rome, italy. part i. prevalence data in men. t... 3720369 - Trace of metal exposure in hard metal lung disease. 8886089 - Obesity and osteoarthritis of the hands in women. |
Publication Detail:
|
Type: Journal Article Date: 2011-10-03 |
Journal Detail:
|
Title: F1000 biology reports Volume: 3 ISSN: 1757-594X ISO Abbreviation: F1000 Biol Rep Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101506835 Medline TA: F1000 Biol Rep Country: England |
Other Details:
|
Languages: eng Pagination: 22 Citation Subset: - |
Affiliation:
|
Evelyn F. McKnight Brain Institute and Departments of Psychology and Neurology, University of Arizona Life Sciences North, Rm 355, Tucson, AZ 85724-5115 USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adenosine receptors and fibrosis: a translational review.
Next Document: Assessing and accounting for time heterogeneity in stochastic actor oriented models.