Document Detail

Secretory villous adenomas that cause depletion syndrome.
MedLine Citation:
PMID:  10219936     Owner:  NLM     Status:  MEDLINE    
Secretory villous adenomas of the colon have been known to cause a depleting syndrome characterized by dehydration, prerenal azotemia, hyponatremia, hypokalemia, metabolic acidosis, obtundation, and, in severe cases, death. We describe 1 case of classic depleting syndrome and review the literature on possible mechanisms. Both cyclic adenosine monophosphate and prostaglandin E2 have been implicated as possible secretagogue compounds in the pathogenesis of this syndrome unique to the secretory variant form of villous adenomas. Indomethacin as a prostaglandin inhibitor has been used with apparent benefit in controlling the volume of rectal effluent in patients with secretory villous adenomas.
J Older; P Older; J Colker; R Brown
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  159     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-05     Completed Date:  1999-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-80     Citation Subset:  AIM; IM    
Department of Medicine, Berkshire Medical Center, Pittsfield, Massachusetts 01201, USA.
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MeSH Terms
Adenoma, Villous / complications,  diagnosis*,  surgery
Diagnosis, Differential
Diarrhea / etiology*
Rectal Neoplasms / complications,  diagnosis*,  surgery
Water-Electrolyte Imbalance / etiology*

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