| Secretory and vascular effects of the optical isomers of nicardipine. | |
| | |
MedLine Citation:
|
PMID: 6713732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog-isolated, blood-perfused pancreas. Intra-arterial administration of (-)-nicardipine (10-300 micrograms) caused a dose-dependent increase in pancreatic secretion. However, the (+)-isomer was much less potent than the (-)-isomer and even in 300 micrograms of (+)-isomer caused only a slight secretion. (+)- And (-)-nicardipine increased perfusion blood flow in a dose-dependent manner, and (+)-nicardipine was approximately five times as potent as the (-)-isomers. The maximum increase in a flow rate was produced by 30 micrograms of (+)-isomer and 100 micrograms of (-)-isomer. Bicarbonate concentration in pancreatic juice induced by (-)- and (+)-nicardipine was increased in a dose-dependent manner, but the protein concentration was only increased slightly. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine. |
| | |
Authors:
|
K Iwatsuki; F Iijima; S Chiba |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 11 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1984 Jan-Feb |
Date Detail:
|
Created Date: 1984-06-19 Completed Date: 1984-06-19 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bicarbonates / analysis Dogs Dose-Response Relationship, Drug Female Male Nicardipine Nifedipine / analogs & derivatives*, pharmacology Pancreas / blood supply, drug effects*, secretion Pancreatic Juice / analysis Proteins / analysis Regional Blood Flow / drug effects Stereoisomerism |
| Chemical | |
Reg. No./Substance:
|
0/Bicarbonates; 0/Proteins; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of antibody and complement in the cellular response to Trypanosoma congolense.
Next Document: Elimination of hyaluronic acid from the blood stream in the human.