Document Detail


Secretory and vascular effects of the optical isomers of nicardipine.
MedLine Citation:
PMID:  6713732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog-isolated, blood-perfused pancreas. Intra-arterial administration of (-)-nicardipine (10-300 micrograms) caused a dose-dependent increase in pancreatic secretion. However, the (+)-isomer was much less potent than the (-)-isomer and even in 300 micrograms of (+)-isomer caused only a slight secretion. (+)- And (-)-nicardipine increased perfusion blood flow in a dose-dependent manner, and (+)-nicardipine was approximately five times as potent as the (-)-isomers. The maximum increase in a flow rate was produced by 30 micrograms of (+)-isomer and 100 micrograms of (-)-isomer. Bicarbonate concentration in pancreatic juice induced by (-)- and (+)-nicardipine was increased in a dose-dependent manner, but the protein concentration was only increased slightly. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine.
Authors:
K Iwatsuki; F Iijima; S Chiba
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  11     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-06-19     Completed Date:  1984-06-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bicarbonates / analysis
Dogs
Dose-Response Relationship, Drug
Female
Male
Nicardipine
Nifedipine / analogs & derivatives*,  pharmacology
Pancreas / blood supply,  drug effects*,  secretion
Pancreatic Juice / analysis
Proteins / analysis
Regional Blood Flow / drug effects
Stereoisomerism
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Proteins; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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