Document Detail


Secretory patterns of glucoregulatory hormones in prehepatic circulation of dogs.
MedLine Citation:
PMID:  2861748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The temporal organization of patterns of secretion of insulin, glucagon, and somatostatin was studied in basal conditions in normal or pancreatectomized dogs fitted with an indwelling hepatic portal catheter. Portal and peripheral blood samples were collected at a 7.5- or 15-min frequency, which covered the medium range of the ultradian period. The raw data were studied using spectral analyses employing fast Fourier transformation (FFT) techniques. The results indicate that in normal dogs: 1) endogenous physiological periodicities, statistically significant at a level of alpha = 0.05 (i.e., 95% confidence interval), were found to exist for the three pancreatic hormones in portal blood between 0.54 and 1.78 h/cycle and in peripheral blood between 0.59 and 1.84 h/cycle; 2) the portal levels of the hormones are significantly higher than peripheral ones; and, 3) whereas pancreatic hormones oscillated, glucose was found to maintain a steady level. In pancreatectomized dogs, no regular rhythm was detected. Thus, whereas endogenous periodicities exist for the secretion of pancreatic hormones in the normal dog, in the pancreatectomized dog the extrapancreatic glucagon and somatostatin are secreted in nonperiodic, randomly occurring pulses.
Authors:
A Sirek; P Vaitkus; K H Norwich; O V Sirek; R H Unger; V Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E34-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Dogs
Female
Glucagon / blood
Immunoassay
Insulin / blood
Male
Pancreatectomy
Pancreatic Hormones / blood,  secretion*
Periodicity
Portal Vein
Saphenous Vein
Somatostatin / blood
Statistics as Topic
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Pancreatic Hormones; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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