Document Detail

Secretory lysozyme of the human middle ear mucosa: immunocytochemical localization.
MedLine Citation:
PMID:  944008     Owner:  NLM     Status:  MEDLINE    
Lysozyme was demonstrated by an immunocytochemical technique in the biopsied mucosa obtained from the promontory of the fifteen patients who had chronic middle ear effusions. Lysozyme was localized in the mucigen granules of the secretory cells, as well as in the specific granules of the polymorphonuclear neutrophilic leukobytes (PMN) and macrophages. The specimens obtained from patients with mucous effusion showed numerous secretory cells that contained lysozyme, in sharp contrast to the serous type in which only a few secretory cells could be found. The present morphological finding was in agreement with the biochemical finding which demonstrated higher lysozyme level in mucous effusions than that of the serous type. It was concluded that human middle ear mucosa provided lysozyme and that its secretion was active in serous otitis media, particularly of mucoid type.
D J Lim; Y S Liu; H Birck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  85     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:    1976 Jan-Feb
Date Detail:
Created Date:  1976-05-18     Completed Date:  1976-05-18     Revised Date:  2006-05-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-60     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Cytoplasmic Granules / ultrastructure
Ear, Middle / enzymology*,  ultrastructure
Exudates and Transudates / enzymology
Macrophages / enzymology
Mucous Membrane / enzymology,  ultrastructure
Muramidase / immunology,  metabolism*
Neutrophils / enzymology
Otitis Media / enzymology
Reg. No./Substance:

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