| Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism. | |
| | |
MedLine Citation:
|
PMID: 3941166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report a patient with neonatal severe primary hyperparathyroidism whose parathyroid cells were markedly refractory to regulation by calcium in vitro. He showed life-threatening hypercalcemia (4.8-5.2 mM vs. normal of 2.1-2.7 mM). A sibling had been treated previously for an identical disorder. At age 6.5 months, four hyperplastic parathyroid glands were removed, and portions of one were immediately grafted into the forearm. Serum calcium again became elevated post-operatively and then fall to the normal range after excision of grafted parathyroid tissue. Dispersed parathyroid cells from the first operation showed no suppression of PTH secretion by 2 mM calcium; however, there was normal maximal suppressibility at 4 mM calcium with half-maximal suppression at 2.53 mM (the calcium set point). This contrasts with much lower set points previously established for suppressible cells from normal (1.02 +/- 0.10 mM, mean +/- 1 SD), from primary hyperplastic (1.10 +/- 0.14 mM), or from adenomatous (1.26 +/- 0.14 mM) parathyroid glands. The strikingly high set point may not be unique because a small number of glands previously classified as nonsuppressible (by the criterion of failing to suppress below 50% maximum at calcium concentration up to 2-3 mM) might have shown similarly high set points if tested at higher calcium concentrations. We conclude that an unusual abnormality of PTH secretory control accounts, in large part, for both the marked hypercalcemia and for its refractoriness to surgical treatment in this patient. |
| | |
Authors:
|
S J Marx; R D Lasker; E M Brown; L A Fitzpatrick; N B Sweezey; R B Goldbloom; D A Gillis; D E Cole |
Related Documents
:
|
6602556 - Duodenal and ileal calcium absorption in the rat and effects of vitamin d. 18411126 - Advances in techniques for measurement of parathyroid hormone current applications in c... 7503746 - Pulsating fluid flow increases nitric oxide (no) synthesis by osteocytes but not perios... 8691746 - Phosphate transport in osteoclasts: a functional and immunochemical characterization. 2321786 - Direct effect of halothane and isoflurane on the function of the sarcoplasmic reticulum... 18614626 - A reappraisal of the factors involved in in vitro initiation of the acrosome reaction i... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 62 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1986 Feb |
Date Detail:
|
Created Date: 1986-02-20 Completed Date: 1986-02-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 445-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Calcium
/
physiology Humans Hypercalcemia / physiopathology Hyperparathyroidism / physiopathology* Infant, Newborn Male Parathyroid Glands / secretion* Parathyroid Hormone / secretion* |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Contribution of plasma androstenedione to 5 alpha-androstanediol glucuronide in women with idiopathi...
Next Document: Extension-abduction contracture of the spastic hip.