| Secretory anti-Giardia lamblia antibodies in human milk: protective effect against diarrhea. | |
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MedLine Citation:
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PMID: 8265319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether anti-Giardia lamblia secretory IgA (sIgA) antibodies in human milk protect infants from acquisition of or symptoms associated with Giardia infection. METHODS: One hundred ninety-seven Mexican mother/infant pairs were followed weekly from birth for diarrheal disease and feeding status. Infant stool specimens were collected weekly and were cultured for bacterial pathogens and tested for Giardia and rotavirus by enzyme-linked immunosorbent assay. Maternal milk samples were collected weekly for 1 month postpartum and monthly thereafter. To determine the protective effect of anti-Giardia sIgA in milk against infection and against diarrhea due to Giardia, milk samples from mothers of infected infants and appropriately matched controls were assayed for anti-Giardia sIgA by enzyme-linked immunosorbent assay. RESULTS: Asymptomatic, infected infants ingested significantly (P = .046) higher amounts of milk anti-Giardia sIgA compared with symptomatic, infected infants. However, milk anti-Giardia sIgA concentrations did not differ between Giardia-infected and noninfected infants. CONCLUSION: The amount of anti-Giardia sIgA in human milk was associated with prevention of symptoms of diarrhea due to Giardia, but not with acquisition of the organism. |
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Authors:
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J N Walterspiel; A L Morrow; M L Guerrero; G M Ruiz-Palacios; L K Pickering |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatrics Volume: 93 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-01-25 Completed Date: 1994-01-25 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 28-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of the King's Daughters, Norfolk. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Protozoan / analysis* Cohort Studies Diarrhea, Infantile / immunology* Enzyme-Linked Immunosorbent Assay Female Giardia lamblia / immunology* Giardiasis / immunology* Humans Immunity, Maternally-Acquired Immunoglobulin A, Secretory / analysis* Infant Infant, Newborn Milk, Human / immunology* Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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HD-13021/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/Immunoglobulin A, Secretory |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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