| Secretory IgA: arresting microbial pathogens at epithelial borders. | |
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MedLine Citation:
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PMID: 20450284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secretory IgA (SIgA) is the predominant class of antibody found in intestinal secretions. Although SIgA's role in protecting the intestinal epithelium from the enteric pathogens and toxins has long been recognized, surprisingly little is known about the molecular mechanisms by which this is achieved. The present review summarizes the current understanding of how SIgA functions to prevent microbial pathogens and toxins from gaining access to the intestinal epithelium. We also discuss recent work from our laboratory examining the interaction of a particular protective monoclonal IgA with Salmonella and propose, based on this work, that SIgA has a previously unrecognized capacity to directly interfere with microbial virulence at mucosal surfaces. |
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Authors:
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Nicholas J Mantis; Stephen J Forbes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunological investigations Volume: 39 ISSN: 1532-4311 ISO Abbreviation: Immunol. Invest. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-13 Revised Date: 2013-01-14 |
Medline Journal Info:
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Nlm Unique ID: 8504629 Medline TA: Immunol Invest Country: England |
Other Details:
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Languages: eng Pagination: 383-406 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, University at Albany School of Public Health, Albany, New York 12208, USA. nmantis@wadsworth.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immunity, Mucosal / immunology* Immunoglobulin A, Secretory / immunology* Infection / immunology* Intestinal Mucosa / immunology* Intestinal Secretions / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI082059/AI/NIAID NIH HHS; HD061916/HD/NICHD NIH HHS; R01 HD061916/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A, Secretory |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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