| Secretory IgA- and IgG-coated bacteria in the nasopharynx of children. An immunofluorescence study. | |
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MedLine Citation:
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PMID: 1763637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial samples were obtained from the posterior wall of the nasopharynx (NPH) of 18 healthy children (age range 1 to 14 years, 10 males, 8 females) and subjected for immunofluorescence studies using fluorescein-labelled goat anti-human IgG and goat anti-human SIgA antibodies. Quantitative and qualitative bacteriological analyses were performed simultaneously. IgG-coated bacteria in the NPH were observed in 1-year-old subjects and opsonized bacteria seemed to increase in numbers and fluorescence intensity with increasing age. SIgA-coated bacteria appeared later, and intensely fluorescing bacteria were not seen until the age of 3 to 6 years. Thirteen out of the 18 children harboured middle ear pathogens in the NPH, but generally speaking non-pathogens dominated the bacterial flora. Immunoglobulins are of the utmost importance for the mucosal defence system, including protection against bacterial attachment to the epithelial cells (SIgA), and bacteriolysis and opsonization of the bacteria (IgG). |
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Authors:
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L E Stenfors; S Räisänen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 111 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-02-13 Completed Date: 1992-02-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 1139-45 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Tromsö, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Female Fluorescent Antibody Technique Humans Immunoglobulin A, Secretory / immunology* Immunoglobulin G / immunology* Male Mucous Membrane / immunology Nasopharynx / microbiology* Opsonin Proteins / immunology Otitis Media / microbiology Phagocytosis |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A, Secretory; 0/Immunoglobulin G; 0/Opsonin Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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