| Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics. | |
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MedLine Citation:
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PMID: 21917008 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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França EL, Morceli G, Fagundes DLG, Rudge MVC, Calderon I de MP, Honorio-França AC. Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics. APMIS 2011; 119: 710-19. The effects of secretory immunoglobulin A (SIgA) interaction with its specific Fcα receptors on colostral phagocytes needs further investigation, especially with respect to diabetic women. Accordingly, we studied the colostrum of hyperglycemic women to assess SIgA interactions with Fcα receptors of macrophages as well as the functional activity of these cells. The women were divided for colostrum sampling according to their glycemic status: normoglycemia (N = 51), mild hyperglycemia (N = 23), and diabetes (N = 25) groups. We determined the FcαR expression, the IgA on the surface and the surface-bound IgA in colostrum macrophages. We also evaluated the superoxide release and bactericidal killing of these cells. Colostral phagocytes expressed FcαR, contained IgA on the surface and are able to bind to purified SIgA. The bactericidal activity of colostral phagocytes from the hyperglycemic women was similar to that of normoglycemic only when SIgA was used as opsonin. Addition of a MoAb anti-human Fcα receptor resulted in a significant decrease of superoxide release and bacterial killing by macrophages when bacteria were opsonized with purified SIgA, suggesting an interaction between SIgA and FcαR. The stimulatory effects of SIgA on the functional activity of phagocytes therefore protect infants, especially of diabetic women, against intestinal infections. |
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Authors:
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Eduardo Luzía França; Glilciane Morceli; Danny Laura Gomes Fagundes; Marilza Vieira Cunha Rudge; Iracema DE Mattos Paranhos Calderon; Adenilda Cristina Honorio-França |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-18 |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 119 ISSN: 1600-0463 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: - |
Other Details:
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Languages: ENG Pagination: 710-719 Citation Subset: - |
Copyright Information:
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© 2011 The Authors. APMIS © 2011 APMIS. |
Affiliation:
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Post Graduate Program in Immunology and Parasitology of the Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, MT Post Graduate Program in Gynecology, Obstetrics and Mastology of the Botucatu Medical School, Unesp, Botucatu, SP Post Graduate Program in Material Science of the Federal University of Mato Grosso, Barra do Garças, MT, Brazil. |
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