Document Detail

Secretion of sex hormones in dogs with adrenal dysfunction.
MedLine Citation:
PMID:  15742696     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate adrenal sex hormone concentrations in response to ACTH stimulation in healthy dogs, dogs with adrenal tumors, and dogs with pituitary-dependent hyperadrenocorticism (PDH). DESIGN: Prospective study. ANIMALS: 11 healthy control dogs, 9 dogs with adrenal-dependent hyperadrenocorticism (adenocarcinoma [ACA] or other tumor); 11 dogs with PDH, and 6 dogs with noncortisol-secreting adrenal tumors (ATs). PROCEDURE: Hyperadrenocorticism was diagnosed on the basis of clinical signs; physical examination findings; and results of ACTH stimulation test, low-dose dexamethasone suppression test, or both. Dogs with noncortisol-secreting ATs did not have hyperadrenocorticism but had ultrasonographic evidence of an AT. Concentrations of cortisol, androstenedione, estradiol, progesterone, testosterone, and 17-hydroxyprogesterone were measured before and 1 hour after i.m. administration of 0.25 mg of synthetic ACTH. RESULTS: All dogs with ACA, 10 dogs with PDH, and 4 dogs with ATs had 1 or more sex hormone concentrations greater than the reference range after ACTH stimulation. The absolute difference for progesterone, 17-hydroxyprogesterone, and testosterone concentrations (value obtained after ACTH administration minus value obtained before ACTH administration) was significantly greater for dogs with ACA, compared with the other 3 groups. The absolute difference for androstenedione was significantly greater for dogs with ACA, compared with dogs with AT and healthy control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Dogs with ACA secrete increased concentrations of adrenal sex hormones, compared with dogs with PDH, noncortisol-secreting ATs, and healthy dogs. Dogs with noncortisol-secreting ATs also have increased concentrations of sex hormones. There is great interdog variability in sex hormone concentrations in dogs with ACA after stimulation with ACTH.
Kate E Hill; J Catharine R Scott-Moncrieff; Mark A Koshko; Lawrence T Glickman; Nita W Glickman; Richard W Nelson; William E Blevins; Jack W Oliver
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  226     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-03     Completed Date:  2005-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-61     Citation Subset:  IM    
Department of Small Animal Medicine, School of Veterinary Medicine, West Lafayette, IN 47909, USA.
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MeSH Terms
Adrenal Cortex Hormones / blood,  secretion*
Adrenal Cortex Neoplasms / blood,  metabolism,  veterinary*
Adrenocortical Adenoma / blood,  metabolism,  veterinary
Adrenocortical Carcinoma / blood,  metabolism,  veterinary
Adrenocortical Hyperfunction / blood,  metabolism,  veterinary*
Adrenocorticotropic Hormone / blood,  secretion*
Dexamethasone / diagnostic use
Dog Diseases / blood,  metabolism*
Progesterone / blood,  secretion
Prospective Studies
Testosterone / blood,  secretion
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone; 57-83-0/Progesterone; 58-22-0/Testosterone; 9002-60-2/Adrenocorticotropic Hormone

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