| Secretion of sex hormones in dogs with adrenal dysfunction. | |
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MedLine Citation:
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PMID: 15742696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate adrenal sex hormone concentrations in response to ACTH stimulation in healthy dogs, dogs with adrenal tumors, and dogs with pituitary-dependent hyperadrenocorticism (PDH). DESIGN: Prospective study. ANIMALS: 11 healthy control dogs, 9 dogs with adrenal-dependent hyperadrenocorticism (adenocarcinoma [ACA] or other tumor); 11 dogs with PDH, and 6 dogs with noncortisol-secreting adrenal tumors (ATs). PROCEDURE: Hyperadrenocorticism was diagnosed on the basis of clinical signs; physical examination findings; and results of ACTH stimulation test, low-dose dexamethasone suppression test, or both. Dogs with noncortisol-secreting ATs did not have hyperadrenocorticism but had ultrasonographic evidence of an AT. Concentrations of cortisol, androstenedione, estradiol, progesterone, testosterone, and 17-hydroxyprogesterone were measured before and 1 hour after i.m. administration of 0.25 mg of synthetic ACTH. RESULTS: All dogs with ACA, 10 dogs with PDH, and 4 dogs with ATs had 1 or more sex hormone concentrations greater than the reference range after ACTH stimulation. The absolute difference for progesterone, 17-hydroxyprogesterone, and testosterone concentrations (value obtained after ACTH administration minus value obtained before ACTH administration) was significantly greater for dogs with ACA, compared with the other 3 groups. The absolute difference for androstenedione was significantly greater for dogs with ACA, compared with dogs with AT and healthy control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Dogs with ACA secrete increased concentrations of adrenal sex hormones, compared with dogs with PDH, noncortisol-secreting ATs, and healthy dogs. Dogs with noncortisol-secreting ATs also have increased concentrations of sex hormones. There is great interdog variability in sex hormone concentrations in dogs with ACA after stimulation with ACTH. |
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Authors:
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Kate E Hill; J Catharine R Scott-Moncrieff; Mark A Koshko; Lawrence T Glickman; Nita W Glickman; Richard W Nelson; William E Blevins; Jack W Oliver |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the American Veterinary Medical Association Volume: 226 ISSN: 0003-1488 ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-03-03 Completed Date: 2005-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 556-61 Citation Subset: IM |
Affiliation:
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Department of Small Animal Medicine, School of Veterinary Medicine, West Lafayette, IN 47909, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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blood,
secretion* Adrenal Cortex Neoplasms / blood, metabolism, veterinary* Adrenocortical Adenoma / blood, metabolism, veterinary Adrenocortical Carcinoma / blood, metabolism, veterinary Adrenocortical Hyperfunction / blood, metabolism, veterinary* Adrenocorticotropic Hormone / blood, secretion* Animals Dexamethasone / diagnostic use Dog Diseases / blood, metabolism* Dogs Female Male Progesterone / blood, secretion Prospective Studies Testosterone / blood, secretion |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone; 57-83-0/Progesterone; 58-22-0/Testosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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