Document Detail


Secretion of progesterone, estradiol-17beta, PGE, PGF2alpha, and pregnancy-specific protein B by 90-day intact and ovariectomized pregnant ewes.
MedLine Citation:
PMID:  10560616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-day pregnant ewes were either laparotomized, ovaries left in situ or bilaterally ovariectomized, and a jugular venous catheter and an inferior vena cava catheter via the saphenous vein were installed. Seven days later, placenta slices were collected and incubated in vitro for 4 h. Secretions of progesterone, PGE, estradiol-17beta and pregnancy-specific protein B (PSPB) in vitro by placenta from ovariectomized ewes were increased (P < or = 0.05) by 2.7-, 3.6-, 2.2-, and 2.4-fold, respectively, when compared to placenta slices from intact 90-day pregnant ewes. Secretion of PGF2alpha in vitro was unchanged (P > or = 0.05). Ovariectomy decreased (P < or = 0.05) jugular venous progesterone for 78 h followed by a quadratic increase (P < or = 0.05), whereas progesterone remained unchanged (P > or = 0.05) in intact ewes over the 162-h sampling period. Ovariectomy increased (P < or = 0.05) PGE in inferior vena cava plasma over the last half of the 162-h sampling period, whereas concentration of PGF2alpha did not change (P > or = 0.05). Increases in PGE occurred before the increase in progesterone. Concentrations of PSPB in inferior vena cava plasma of ovariectomized pregnant ewes increased (P < or = 0.05) during the last half of the 162-h sampling period, but not in intact ewes (P > or = 0.05). PSPB increased before PGE and progesterone. Concentrations of estradiol-17beta in jugular venous plasma of ovariectomized pregnant ewes increased (P < or = 0.05) during the last half of the sampling period, but not in intact ewes (P > or = 0.05). Increases in estradiol-17beta occurred before increases in PSPB. It is concluded that these data support the hypothesis that estradiol-17beta may control placental secretion of PSPB; PSPB may regulate placental secretion of PGE; and PGE may regulate placental secretion of progesterone.
Authors:
Y S Weems; P J Bridges; B R LeaMaster; R G Sasser; D L Vincent; C W Weems
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  58     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-48     Citation Subset:  IM    
Affiliation:
Department of Animal Science, University of Hawaii, Honolulu 96822, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid Endopeptidases / blood*
Dinoprost / blood*
Estradiol / blood*
Female
Laparotomy
Ovariectomy
Placenta / metabolism
Pregnancy
Pregnancy Proteins / blood*
Pregnancy, Animal / blood,  physiology*
Progesterone / blood*
Prostaglandins E / blood*
Sheep / blood,  physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 0/Prostaglandins E; 50-28-2/Estradiol; 551-11-1/Dinoprost; 57-83-0/Progesterone; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.23.-/pregnancy-associated glycoprotein 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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