| Secretion of plasminogen activator by rheumatoid and nonrheumatoid synovial cells in culture. | |
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MedLine Citation:
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PMID: 901594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The secretion of plasminogen activator by human synovial cultures established from explants was studied. Thirteen cultures established from patients with rheumatoid disease were hyposecretors of plasminogen activator. Seven cultures derived from patients with nonrheumatoid joint disorders all secreted high levels of this enzyme. Rheumatoid and nonrheumatoid cells contained comparable levels of intracellular activator. It is suggested that the secretion of plasminogen activator is a function of normal synovium and that a defect in this function in the rheumatoid synovium perpetuates the inflammatory process. |
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Authors:
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H Berger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 20 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1977 Jul-Aug |
Date Detail:
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Created Date: 1977-10-14 Completed Date: 1977-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1198-205 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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pathology* Blood Cell Line Cells, Cultured Culture Media Humans Kinetics Plasminogen Activators / secretion* Synovial Membrane / pathology, secretion* |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; EC 3.4.21.-/Plasminogen Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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