| Secretion of inhibin A and inhibin B throughout pregnancy and the early postpartum period in chimpanzees. | |
| | |
MedLine Citation:
|
PMID: 11182763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Plasma concentrations of inhibin A and inhibin B during pregnancy and early lactation in chimpanzees were determined by enzyme-linked immunosorbent assay (ELISA). Plasma samples were taken from five pregnant chimpanzees at 6-9, 10, 20 and 25 weeks of pregnancy, and following parturition. Throughout pregnancy and the early postpartum period, circulating inhibin A and inhibin B concentrations remained low, at similar levels to those during the normal menstrual cycle in chimpanzees. Concentrations of inhibin A in the placental homogenate were high enough to be measured by the ELISA and by bioassay, whereas circulating inhibin bioactivities in late pregnancy were too low to be measured. Plasma concentrations of FSH remained low with no significant changes throughout pregnancy and the postpartum period. Plasma concentrations of oestradiol-17beta and progesterone at 25 weeks of pregnancy were much higher than normal menstrual cycle levels. It was concluded that in chimpanzees the levels of circulating inhibin A and inhibin B remained low throughout pregnancy and the early postpartum period, and that the concentrations of bioactive dimeric inhibin did not increase towards the end of pregnancy. The suppression of circulating FSH levels during pregnancy is suggested to be controlled by steroid hormones that increased significantly in late pregnancy, and the present findings further suggest that the secretory pattern and role of inhibin during pregnancy in chimpanzees may be different from that in human and other primates. |
| | |
Authors:
|
M Kondo; M Kondo; T Udono; W Z Jin; W Z Jin; M Funakoshi; K Shimizu; M Itoh; C B Herath; G Watanabe; G Watanabe; N P Groome; K Taya; K Taya |
Related Documents
:
|
8014693 - Intravenous gamma globulin administration to common variable immunodeficient women duri... 455143 - Serum msh levels and pituitary msh content: their fluctuation during pregnancy in the rat. 7330773 - Placental findings in spontaneous abortions and stillbirths. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 168 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-02-22 Completed Date: 2001-03-22 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
|
Novartis Animal Health, Tokyo 105-6134, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Enzyme-Linked Immunosorbent Assay Estradiol / blood Female Follicle Stimulating Hormone / blood Humans Inhibins / blood* Luteinizing Hormone / blood Pan troglodytes / blood* Placenta / metabolism Postpartum Period / blood Pregnancy Pregnancy Proteins / blood* Pregnancy, Animal / blood* Progesterone / blood Species Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Pregnancy Proteins; 50-28-2/Estradiol; 57-83-0/Progesterone; 57285-09-3/Inhibins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibitory effects of nitric oxide on estrogen production and cAMP levels in rat granulosa cell cult...
Next Document: Expression of prostanoid receptor genes in baboon chorion and decidua during pregnancy and parturiti...