| Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? | |
| | |
MedLine Citation:
|
PMID: 20871975 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The incretin hormones gastric inhibitory polypeptide and especially glucagon-like peptide (GLP) have an important physiological function in augmenting postprandial insulin secretion. Since GLP-1 may play a role in the pathophysiology and treatment of type 2 diabetes, assessment of meal-related GLP-1 secretory responses in type 2 diabetic patients vs healthy individuals is of great interest. A common view states that GLP-1 secretion in patients with type 2 diabetes is deficient and that this applies to a lesser degree in individuals with impaired glucose tolerance. Such a deficiency is the rationale for replacing endogenous incretins with GLP-1 receptor agonists or re-normalising active GLP-1 concentrations with dipeptidyl peptidase-4 inhibitors. This review summarises the literature on this topic, including a meta-analysis of published studies on GLP-1 secretion in individuals with and without diabetes after oral glucose and mixed meals. Our analysis does not support the contention of a generalised defect in nutrient-related GLP-1 secretory responses in type 2 diabetes patients. Rather, factors are identified that may determine individual incretin secretory responses and explain some of the variations in published findings of group differences in GLP-1 responses to nutrient intake. |
| | |
Authors:
|
M A Nauck; I Vardarli; C F Deacon; J J Holst; J J Meier |
Related Documents
:
|
18755155 - Dpp4 inhibitors for diabetes--what next? 3901165 - Preserved incretin effect after complete surgical denervation of the pancreas in young ... 17676345 - 3d-qsar studies of dipeptidyl peptidase iv inhibitors using a docking based alignment. 16435485 - Depression of insulin release by anti-gip serum after oral glucose in rats. 8432105 - Number of amalgam fillings in relation to cardiovascular disease, diabetes, cancer and ... 7132235 - Adrenergic mechanisms and blood pressure regulation in diabetes mellitus. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-25 |
Journal Detail:
|
Title: Diabetologia Volume: 54 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
|
Languages: eng Pagination: 10-8 Citation Subset: IM |
Affiliation:
|
Diabeteszentrum Bad Lauterberg, Bad Lauterberg im Harz, Germany. M.Nauck@diabeteszentrum.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies.
Next Document: Presence of Polychlorinated Biphenyls (PCBs) in Bottled Drinking Water in Mexico City.