| Secretion and clearance rates of glucagon in dairy cows. | |
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MedLine Citation:
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PMID: 3519704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight Holstein cows were sampled to examine plasma concentrations of hormones and some energy related metabolites. Sampling was every hour for 12 h at about 2 wk prepartum, at 3 wk postpartum, during an energy restriction ketonemia, and after a recovery period. Cows were fed ad libitum except for four cows induced into ketonemia by restricting feed intake 50%. Pulse doses of glucagon were injected intravenously during each period. Feed restriction increased concentrations of growth hormone, acetoacetate, beta-hydroxybutyrate, and free fatty acids in blood plasma. Concentrations of insulin and glucose showed some tendencies to decrease. Distribution space and turnover rate of glucagon were not different between periods, and pool size was increased in the dry period. Metabolic clearance rate of glucagon was not significantly different between periods. Insulin and glucose concentrations were increased 1 to 2 min after injection of glucagon and remained increased for 25 min. Covariance analysis showed that glucagon injection caused glucose concentration to increase proportionally in all periods, suggesting that cows had equal gluconeogenic capacity in all periods. Basal concentration, pool size, and secretion rate of glucagon showed some tendency to be decreased during ketonemia. |
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Authors:
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G De Boer; A Trenkle; J W Young |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of dairy science Volume: 69 ISSN: 0022-0302 ISO Abbreviation: J. Dairy Sci. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-07-07 Completed Date: 1986-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985126R Medline TA: J Dairy Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 721-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetoacetates
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blood Animals Blood Glucose / metabolism Cattle / metabolism* Fatty Acids, Nonesterified / blood Female Glucagon / administration & dosage, blood, metabolism*, secretion Growth Hormone / blood Hydroxybutyrates / blood Insulin / blood Ketone Bodies / blood* Kinetics Lactation* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Acetoacetates; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Ketone Bodies; 11061-68-0/Insulin; 9002-72-6/Growth Hormone; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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