Document Detail


Secretion and clearance of immunoreactive ACTH by fetal lung.
MedLine Citation:
PMID:  7762636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously reported the presence of immunoreactive adrenocorticotropic hormone (irACTH) in fetal and adult ovine lung and secretion of the irACTH into the pulmonary venous blood during surgical stress. The aim of the present experiments was to determine whether the fetal lung secretes irACTH during less stressful conditions. Seven fetal sheep were chronically prepared with systemic, pulmonary arterial, and pulmonary venous catheters. After recovery from surgery, paired samples were obtained from the pulmonary arterial and venous catheters. In 51 pairs of samples, we quantified the arteriovenous (A-V) difference in plasma irACTH concentration. Pulmonary A-V difference in plasma irACTH was significantly related to the arterial plasma concentration of irACTH but not to fetal blood gases, pH, or gestational age. Regression analysis revealed that, at arterial plasma concentrations of irACTH less than approximately 200 pg/ml, the lung releases irACTH into plasma and that, at higher concentrations, the lung clears irACTH from the plasma. We conclude that the lung independently secretes and clears irACTH into and from plasma.
Authors:
T A Cudd; C E Wood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E845-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Florida College of Medicine, Gainesville 32610-0274, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / metabolism*
Animals
Arteries
Fetal Blood / metabolism
Fetus / metabolism*
Lung / embryology*
Osmolar Concentration
Radioimmunoassay
Regression Analysis
Sheep
Veins
Grant Support
ID/Acronym/Agency:
HD-24250/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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