Document Detail


Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection.
MedLine Citation:
PMID:  10882085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Japanese encephalitis (JE) virus infection induces infiltration of neutrophils in neural as well as extraneural tissues in patients. As interleukin-8 (IL-8) has inflammatory properties, the present study was undertaken to investigate the IL-8 concentrations in cerebrospinal fluid (CSF) and serum from patients with JE and correlate them with neutrophil counts. IL-8 was measured in the CSF or serum of 30 patients with confirmed JE. The majority (92%) of the acute CSF samples showed raised levels of IL-8 with raised numbers of polymorphonuclear leucocytes. Similarly, significantly higher serum IL-8 concentrations were detected in the acute phase of illness than in convalescent JE patients or normal healthy controls. Twenty-one of 25 patients with high concentrations of IL-8 showed significantly increased neutrophil counts in acute phase sera. A gradual decline in neutrophil counts was observed in the convalescent phase of patients who recovered. There was a significant correlation between IL-8 level and the severity of illness, as all severely ill and fatal cases showed higher levels of IL-8 in acute CSF or serum than the levels found in those who recovered. IL-8 concentrations remained high for a longer period in patients with prolonged severe illness than in those who made a complete recovery.
Authors:
A Singh; R Kulshreshtha; A Mathur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  49     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Affiliation:
Postgraduate Department of Microbiology, KG Medical College, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Child
Child, Preschool
Convalescence
Encephalitis, Japanese / immunology*
Humans
Interleukin-8 / blood*,  cerebrospinal fluid*
Leukocyte Count
Neutrophils / cytology,  immunology*
Chemical
Reg. No./Substance:
0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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