Document Detail

Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection.
MedLine Citation:
PMID:  10882085     Owner:  NLM     Status:  MEDLINE    
Japanese encephalitis (JE) virus infection induces infiltration of neutrophils in neural as well as extraneural tissues in patients. As interleukin-8 (IL-8) has inflammatory properties, the present study was undertaken to investigate the IL-8 concentrations in cerebrospinal fluid (CSF) and serum from patients with JE and correlate them with neutrophil counts. IL-8 was measured in the CSF or serum of 30 patients with confirmed JE. The majority (92%) of the acute CSF samples showed raised levels of IL-8 with raised numbers of polymorphonuclear leucocytes. Similarly, significantly higher serum IL-8 concentrations were detected in the acute phase of illness than in convalescent JE patients or normal healthy controls. Twenty-one of 25 patients with high concentrations of IL-8 showed significantly increased neutrophil counts in acute phase sera. A gradual decline in neutrophil counts was observed in the convalescent phase of patients who recovered. There was a significant correlation between IL-8 level and the severity of illness, as all severely ill and fatal cases showed higher levels of IL-8 in acute CSF or serum than the levels found in those who recovered. IL-8 concentrations remained high for a longer period in patients with prolonged severe illness than in those who made a complete recovery.
A Singh; R Kulshreshtha; A Mathur
Related Documents :
17702265 - Csf hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic cns hypersom...
17521035 - Primary gastrointestinal lymphangiectasia presenting as cryptococcal meningitis.
3786215 - Use of thermogram in detection of meningitis.
2332325 - Scinticisternography in presenile and senile degenerative disease.
17143005 - Barriers to stroke thrombolysis in a geographically defined population.
3391155 - The prevention of chronic epilepsy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  49     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Postgraduate Department of Microbiology, KG Medical College, Lucknow, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Child, Preschool
Encephalitis, Japanese / immunology*
Interleukin-8 / blood*,  cerebrospinal fluid*
Leukocyte Count
Neutrophils / cytology,  immunology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Amphotericin B resistance of Aspergillus terreus in a murine model of disseminated aspergillosis.
Next Document:  A potential role for tumour necrosis factor-alpha in synergy between porcine respiratory coronavirus...