Document Detail


Secretion of Streptomyces mobaraensis pro-transglutaminase by coryneform bacteria.
MedLine Citation:
PMID:  18219481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously reported on the secretion of Streptomyces mobaraensis transglutaminase by Corynebacterium glutamicum ATCC13869 (formerly classified as Brevibacterium lactofermentum). In the present work, we investigated whether any other coryneform bacteria showed higher productivity than C. glutamicum ATCC13869. We found that most coryneform species secreted pro-transglutaminase efficiently. Moreover, we confirmed that Corynebacterium ammoniagenes ATCC6872 produced about 2.5 g/l pro-transglutaminase over a 71-h period in a jar fermentor. Our findings suggest that some other coryneform bacteria, especially C. ammoniagenes ATCC6872, are potential hosts for industrial scale protein production.
Authors:
Hiroshi Itaya; Yoshimi Kikuchi
Publication Detail:
Type:  Journal Article     Date:  2008-01-25
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  78     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-06-17     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  621-5     Citation Subset:  IM    
Affiliation:
Institute of Life Sciences, Ajinomoto Co. Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacterial Proteins / chemistry,  genetics,  metabolism
Biomass
Bioreactors
Corynebacterium / genetics*,  metabolism
Genetic Engineering
Industrial Microbiology*
Protein Precursors / chemistry,  genetics,  metabolism*
Protein Sorting Signals
Protein Transport
Streptomyces / enzymology*
Transglutaminases / chemistry,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Protein Precursors; 0/Protein Sorting Signals; EC 2.3.2.13/Transglutaminases
Comments/Corrections

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