| Secretion of Streptomyces mobaraensis pro-transglutaminase by coryneform bacteria. | |
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MedLine Citation:
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PMID: 18219481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported on the secretion of Streptomyces mobaraensis transglutaminase by Corynebacterium glutamicum ATCC13869 (formerly classified as Brevibacterium lactofermentum). In the present work, we investigated whether any other coryneform bacteria showed higher productivity than C. glutamicum ATCC13869. We found that most coryneform species secreted pro-transglutaminase efficiently. Moreover, we confirmed that Corynebacterium ammoniagenes ATCC6872 produced about 2.5 g/l pro-transglutaminase over a 71-h period in a jar fermentor. Our findings suggest that some other coryneform bacteria, especially C. ammoniagenes ATCC6872, are potential hosts for industrial scale protein production. |
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Authors:
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Hiroshi Itaya; Yoshimi Kikuchi |
Publication Detail:
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Type: Journal Article Date: 2008-01-25 |
Journal Detail:
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Title: Applied microbiology and biotechnology Volume: 78 ISSN: 0175-7598 ISO Abbreviation: Appl. Microbiol. Biotechnol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-11 Completed Date: 2008-06-17 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 8406612 Medline TA: Appl Microbiol Biotechnol Country: Germany |
Other Details:
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Languages: eng Pagination: 621-5 Citation Subset: IM |
Affiliation:
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Institute of Life Sciences, Ajinomoto Co. Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Bacterial Proteins / chemistry, genetics, metabolism Biomass Bioreactors Corynebacterium / genetics*, metabolism Genetic Engineering Industrial Microbiology* Protein Precursors / chemistry, genetics, metabolism* Protein Sorting Signals Protein Transport Streptomyces / enzymology* Transglutaminases / chemistry, genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Protein Precursors; 0/Protein Sorting Signals; EC 2.3.2.13/Transglutaminases |
| Comments/Corrections | |
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