| Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. | |
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MedLine Citation:
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PMID: 21030011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD8(+) T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p<0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication. |
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Authors:
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Kevin O Saunders; Cavin Ward-Caviness; Robert J Schutte; Stephanie A Freel; R Glenn Overman; Nathan M Thielman; Coleen K Cunningham; Thomas B Kepler; Georgia D Tomaras |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-27 |
Journal Detail:
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Title: Cellular immunology Volume: 266 ISSN: 1090-2163 ISO Abbreviation: Cell. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 154-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA. Kevin.saunders@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation CD8-Positive T-Lymphocytes / immunology* Chemokine CCL3 / metabolism* Chemokine CCL4 / metabolism* Chemokine CXCL10 / metabolism Down-Regulation / immunology Gene Expression HIV Infections / immunology* HIV-1 / immunology* Histones / immunology Humans Interferon-gamma / metabolism Up-Regulation Valproic Acid / immunology Virus Replication / immunology |
| Grant Support | |
ID/Acronym/Agency:
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F31-AI-078715/AI/NIAID NIH HHS; P30-AI-64518/AI/NIAID NIH HHS; R01-AI-052779/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CCL3 protein, human; 0/CCL4 protein, human; 0/CXCL10 protein, human; 0/Chemokine CCL3; 0/Chemokine CCL4; 0/Chemokine CXCL10; 0/Histones; 82115-62-6/Interferon-gamma; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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