| Secretin and pancreatic islet blood flow in anesthetized rats: increased insulin secretion with no augmentation of blood perfusion. | |
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MedLine Citation:
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PMID: 11572020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secretin is a stimulator of both endocrine and exocrine secretions of the pancreas, and we aimed to evaluate its effects on splanchnic blood flow in rats with a microsphere technique. Anesthetized rats were infused with secretin (0.5 or 2.0 micrograms/kg body weight/hr) for 10 minutes. Some animals were normoglycemic, whereas other received a glucose injection 3 minutes before blood flow measurements. Secretin did not affect serum insulin concentrations in normoglycemic animals but consistently led to higher insulin concentrations in the hyperglycemic rats. Total pancreatic blood flow was increased by the highest secretin dose in normoglycemic animals, whereas no effects were seen in the hyperglycemic rats. Administration of glucose caused a pronounced increase in islet and fractional islet blood flow in saline-infused animals. Secretin affected neither islet nor fractional blood flow in normoglycemic or hyperglycemic rats. Glucose administration increased duodenal blood flow in animals infused with saline and both duodenal and colonic blood flow in rats given the lowest dose of secretin. No effects on either colonic or duodenal blood perfusion were seen in animals infused with the highest dose of secretin. Secretin mainly affects blood flow to the whole pancreas and not that of the islets. Furthermore, glucose-induced insulin release can be achieved without a simultaneous increase in islet blood flow; that is these two events may be dissociated from one another. |
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Authors:
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P O Carlsson; L Jansson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of surgery Volume: 25 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-09-26 Completed Date: 2001-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 835-9 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Biomedical Centre, Box 571, SE-751 23 Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anesthesia Animals Blood Glucose / analysis Disease Models, Animal Dose-Response Relationship, Drug Glucose / administration & dosage* Hyperglycemia / blood, chemically induced* Insulin / blood, secretion* Islets of Langerhans / blood supply*, drug effects*, secretion Male Microspheres Rats Rats, Sprague-Dawley Secretin / pharmacology* Splanchnic Circulation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 1393-25-5/Secretin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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