Document Detail

Secretin-induced gastrin response in the Zollinger-Ellison syndrome and chronic duodenal ulcer patients before and after cimetidine treatment.
MedLine Citation:
PMID:  6720654     Owner:  NLM     Status:  MEDLINE    
A secretin provocative test was performed in 16 patients with chronic duodenal ulcer and in five patients with the Zollinger-Ellison syndrome. In four chronic duodenal ulcer patients a second secretin test was done during acute iv cimetidine administration. There were only slight variations of gastrin compared with the first test. A third test was done on the same four chronic duodenal ulcer patients after 1 month's po cimetidine treatment (1 g/day); gastrin at 0 time was significantly higher than in the previous two tests (p less than 0.01). Integrated gastrin response after secretin was significantly lower in the third test than in the first (p less than 0.05). In two Zollinger-Ellison syndrome patients treated with 1.0 and 1.4 g/day cimetidine for 3 months, gastrin at 0 time was not markedly increased, whereas compared with the first test gastrin levels were higher at each time after secretin. These data suggest that previous cimetidine treatment does not alter, and may even increase, the diagnostic sensitivity of the secretin test.
M Quatrini; G Basilisco; D Conte; M T Bardella; A Bozzani; P A Bianchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  79     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-06     Completed Date:  1984-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  345-7     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Cimetidine / therapeutic use*
Duodenal Ulcer / diagnosis*,  drug therapy
Gastrins / blood
Middle Aged
Secretin / diagnostic use*
Zollinger-Ellison Syndrome / diagnosis*,  drug therapy
Reg. No./Substance:
0/Gastrins; 1393-25-5/Secretin; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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