Document Detail

Secreted phospholipases A(2): A proinflammatory connection between macrophages and mast cells in the human lung.
MedLine Citation:
PMID:  19628294     Owner:  NLM     Status:  MEDLINE    
Secretory phospholipases A(2) (sPLA(2)) are an emerging class of mediators of inflammation. These enzymes accumulate in plasma and other biological fluids of patients with inflammatory, autoimmune and allergic diseases. sPLA(2)s are secreted at low levels in the normal airways and tend to increase during inflammatory lung diseases (e.g. bronchial asthma, chronic obstructive pulmonary disease, interstitial lung fibrosis, and sarcoidosis) as the result of plasma extravasation and/or local production. Such immune resident cells as macrophages and mast cells can be a source of sPLA(2)s in the lung. However, these cells are also targets for sPLA(2)s that sustain the activation programs of macrophages and mast cells with mechanism related to their enzymatic activity as well as to their capacity to interact with surface molecules (e.g., heparan sulfate proteoglycans, M-type receptor, mannose receptor). Recent evidence suggests that mast cells are a better source of extracellular sPLA(2)s than macrophages. On the other hand, macrophages appear to be a preferential target for sPLA(2)s. Anatomical association between macrophages and mast cells in the airways suggest that sPLA(2)s released by mast cells may activate in a paracrine fashion several macrophage functions relevant to the modulation of lung inflammation. Thus, sPLA(2)s may play a major role in inflammatory lung diseases by acting as a proinflammatory connection between macrophages and mast cells.
Francescopaolo Granata; Vincenza Nardicchi; Stefania Loffredo; Annunziata Frattini; Rosaria Ilaria Staiano; Carlo Agostini; Massimo Triggiani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-07-22
Journal Detail:
Title:  Immunobiology     Volume:  214     ISSN:  1878-3279     ISO Abbreviation:  Immunobiology     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  811-21     Citation Subset:  IM    
Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Autocrine Communication
Lung / immunology*
Macrophages / enzymology,  immunology*
Mast Cells / enzymology,  immunology*
Paracrine Communication
Phospholipases A2, Secretory / metabolism*
Pneumonia / immunology*
Reg. No./Substance:
EC A2, Secretory

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