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γ-Secretase Modulators: Current Status and Future Directions.
MedLine Citation:
PMID:  24418609     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This chapter reviews the current status of γ-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes: acids, imidazoles and related derivatives and natural products. A section on chemical biology and ligand-binding site elucidation studies is also included. The primary source of information is drawn from peer reviewed literature as this permits analysis of PK-PD relationships and subsequent comment. Discussion of the patent literature is included for completeness. From this analysis, the key issues and challenges in the area are highlighted. The review concludes with a summary of the clinical development status and comment on future prospects of the field.
Authors:
Adrian Hall; Toshal R Patel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in medicinal chemistry     Volume:  53     ISSN:  0079-6468     ISO Abbreviation:  Prog Med Chem     Publication Date:  2014  
Date Detail:
Created Date:  2014-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376452     Medline TA:  Prog Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-45     Citation Subset:  IM    
Copyright Information:
© 2014 Elsevier B.V. All rights reserved.
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