Document Detail

γ-Secretase Modulators: Current Status and Future Directions.
MedLine Citation:
PMID:  24418609     Owner:  NLM     Status:  In-Data-Review    
This chapter reviews the current status of γ-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes: acids, imidazoles and related derivatives and natural products. A section on chemical biology and ligand-binding site elucidation studies is also included. The primary source of information is drawn from peer reviewed literature as this permits analysis of PK-PD relationships and subsequent comment. Discussion of the patent literature is included for completeness. From this analysis, the key issues and challenges in the area are highlighted. The review concludes with a summary of the clinical development status and comment on future prospects of the field.
Adrian Hall; Toshal R Patel
Related Documents :
23969519 - Submitting compelling case reports for drug therapy in veterinary patients.
7446389 - Right ventricular endomyocardial fibrosis simulating ebstein's anomaly.
8633659 - Antenatal ultrasonographic findings differentiating complete from partial agenesis of t...
16799319 - An unusual congenital facial anomaly: erectile proboscis-like structure.
3025399 - Multiple duplications of the small intestine.
23742389 - Reviews of acoustical patents.
3487659 - An outbreak of a newly recognized chronic diarrhea syndrome associated with raw milk co...
17061479 - Intestinal lymphangiectasia: a forgotten cause of chronic diarrhea.
23161239 - Primary myelolipoma of the lung: a case of report and review of literature.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in medicinal chemistry     Volume:  53     ISSN:  0079-6468     ISO Abbreviation:  Prog Med Chem     Publication Date:  2014  
Date Detail:
Created Date:  2014-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376452     Medline TA:  Prog Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-45     Citation Subset:  IM    
Copyright Information:
© 2014 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders.
Next Document:  Recent progress in the discovery and development of N-type calcium channel modulators for the treatm...