Document Detail


Secretagogue response in rat pancreatic acinar carcinoma.
MedLine Citation:
PMID:  6288996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The secretion of protein, like cell proliferation, is an integrated response that reflects structural organization of the cell periphery. Stimulation of protein secretion was thus utilized for comparison of integrated responses of the cell periphery in pancreatic acinar carcinoma of the rat and integrated responses in normal rat pancreas. Results of this comparison include: a) The stimulation of protein secretion in acinar carcinoma fragments by carbamylcholine chloride and cholecystokinin octapeptide, pancreatic secretagogues that interact with specific plasma membrane receptors, was only a fraction (one-fifth to one-half) of that observed in normal pancreatic minilobules. b) The Ca2+ ionophore A23187 and the cyclic nucleotide N6,O2'-dibutyryl cyclic AMP, secretagogues that act independently of specific membrane receptors, did not stimulate secretion in the acinar carcinoma. The observed quantitative and qualitative differences in protein secretion indicate fundamental differences in cell periphery organization between the normal and transformed acinar cells of pancreas.
Authors:
J R Warren
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  69     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  969-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / pharmacology
Calcimycin / pharmacology
Carbachol / pharmacology
Carcinoma / secretion*
Cell Membrane / drug effects,  metabolism
Cholecystokinin / pharmacology
Dose-Response Relationship, Drug
Pancreas / drug effects,  secretion
Pancreatic Neoplasms / secretion*
Peptide Fragments / pharmacology
Proteins / metabolism*
Rats
Secretory Rate / drug effects
Sincalide
Temperature
Grant Support
ID/Acronym/Agency:
CA-27443/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Proteins; 25126-32-3/Sincalide; 362-74-3/Bucladesine; 51-83-2/Carbachol; 52665-69-7/Calcimycin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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