Document Detail

Secondary systemic lupus erythematosus: an analysis of 4 cases of uncontrolled hereditary angioedema.
MedLine Citation:
PMID:  17098477     Owner:  NLM     Status:  MEDLINE    
The association of systemic lupus erythematosus and hereditary angioedema (HAE) has formed the basis of numerous case reports and is hypothesised to result from consumption of complement C4 with consequent impaired clearance of apoptotic cells. We describe the development of frank lupus or lupus-like syndrome in four HAE patients with uncontrolled angioedema and low levels of serum C4. Measures that limit hypocomplementaemia in HAE may reduce the incidence of secondary SLE.
Sujoy Khan; Michael D Tarzi; Philip C Doré; W A C Sewell; Hilary J Longhurst
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-11-13
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  123     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-05-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-7     Citation Subset:  IM    
Path Links Immunology, Scunthorpe General Hospital, Scunthorpe, North Lincolnshire, UK.
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MeSH Terms
Angioedema / complications*,  immunology*,  physiopathology
Complement C4 / deficiency*
Lupus Erythematosus, Systemic / complications*,  immunology*,  physiopathology
Middle Aged
Reg. No./Substance:
0/Complement C4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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