| Secondary prophylaxis of invasive fungal infections with combination antifungal therapy and G-CSF-mobilized granulocyte transfusions in three children with hematological malignancies. | |
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MedLine Citation:
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PMID: 16482446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungal infections represent a life-threatening complication for patients receiving chemotherapy or undergoing hematopoietic stem cell transplantation. Historically, antifungal monotherapy is associated with a poor outcome. We treated three children with hematological malignancies and proven fungal infections (one cerebral mold infection, one disseminated Candida infection, one naso-pharyngeal mucor infection) with combination antifungal therapy plus granulocyte-colony-stimulation-factor-mobilized granulocyte transfusions as secondary prophylaxis during subsequent neutropenic episodes. With this approach, the fungal infection was effectively treated, and the anticancer therapy was completed without major delay. All children survived the fungal infection and the underlying malignancy. These experiences illustrate the feasibility of this approach using more than one antifungal agent together with immune-therapy in high-risk patients. |
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Authors:
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Lorenz Grigull; Andreas Beilken; Hansjoerg Schmid; P Kirschner; Karl-Walter Sykora; Christin Linderkamp; Frank Donnerstag; Lilia Goudeva; Hans-Gert Heuft; Karl Welte |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-02-16 |
Journal Detail:
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Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Volume: 14 ISSN: 0941-4355 ISO Abbreviation: Support Care Cancer Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2006-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9302957 Medline TA: Support Care Cancer Country: Germany |
Other Details:
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Languages: eng Pagination: 783-6 Citation Subset: IM |
Affiliation:
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Department of Paediatric Haematology and Oncology, Medizinische Hochschule Hannover, OE 6780, Carl-Neuberg Str. 1, D-30625 Hannover, Germany. Grigull.Lorenz@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antifungal Agents / therapeutic use* Aspergillosis / prevention & control Candidiasis / prevention & control Child, Preschool Combined Modality Therapy Feasibility Studies Female Granulocyte Colony-Stimulating Factor / therapeutic use* Granulocytes* Hematologic Neoplasms / drug therapy, therapy* Hematopoietic Stem Cell Transplantation / adverse effects Humans Leukocyte Transfusion* Male Mucormycosis / prevention & control Mycoses / etiology, prevention & control* Myelodysplastic Syndromes / therapy Neutropenia / complications, etiology Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 143011-72-7/Granulocyte Colony-Stimulating Factor |
| Comments/Corrections | |
Comment In:
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Support Care Cancer. 2007 Feb;15(2):233-4; author reply 235
[PMID:
17036226
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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