| Secondary prevention with lipid lowering therapy in familial hypercholesterolemia: a correlation between new evolution of stenotic lesion and achieved cholesterol levels after revascularization procedures. | |
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MedLine Citation:
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PMID: 10361905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: To assess the value of secondary prevention with lipid lowering therapy following either balloon angioplasty (PTCA) or bypass surgery (CABG) in familial hypercholesterolemia patients, the correlation of the new evolution of stenotic lesions and therapeutically achieved cholesterol levels was studied in 50 patients. METHODS: All surviving patients were followed angiographically after 5 years, and findings were correlated with the annually determined total serum cholesterol (TC) levels. RESULTS: New coronary atherosclerotic plaques were not observed in 18 patients in whom the TC was controlled to <220 mg/dl but in 19 of 32 patients in whom the TC was >220 mg/dl, a new evolution of stenotic lesions was observed angiographically. CONCLUSION: The new evolution of stenotic lesions following revascularization in patients with FH can be controlled significantly by lipid lowering therapy to maintain a TC level of <220 mg/dl, and if diet alone can not achieve it, aggressive medication and even LDL apheresis might be justified. |
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Authors:
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S Fukuzawa; S Ozawa; M Inagaki; S Morooka; T Inoue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 38 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-07-29 Completed Date: 1999-07-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 330-5 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Funabashi Municipal Medical Center, Chiba. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Anticholesteremic Agents / therapeutic use Cholestyramine Resin / therapeutic use Coronary Artery Bypass Coronary Artery Disease / prevention & control* Coronary Disease / therapy Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Hyperlipoproteinemia Type II / blood, drug therapy* Lipids / blood Male Middle Aged Probucol / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 11041-12-6/Cholestyramine Resin; 23288-49-5/Probucol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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