Document Detail

Secondary prevention of recurrent urinary tract infections. Comparison of the effect of placebo, methenamine hippurate, nitrofurantoin and trimethoprim alone.
MedLine Citation:
PMID:  6761854     Owner:  NLM     Status:  MEDLINE    
290 patients with recurrent urinary tract infection were treated with either placebo, methenamine hippurate, nitrofurantoin or trimethoprim. 38.9% of the patients had chronic pyelonephritis and 23.8% azotemia. During the follow-up period of 1 year 63.2% recurred in the placebo group, 34.2% in the methenamine hippurate group, 25.0% in the nitrofurantoin group and 10.4% in the trimethoprim group. 62.5% of the recurrences in the trimethoprim group were associated with trimethoprim-resistant strains. However, such strains appeared only in 6.5% of the patients treated with trimethoprim, compared with 16.2% in the placebo, 8.3% in the nitrofurantoin and 11.0% in the methenamine hippurate groups. Side-effects were mild and occurred most frequently in the nitrofurantoin group (13.9%).
A Kasanen; S Y Junnila; E Kaarsalo; A Hajba; H Sundquist
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  14     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Hippurates / therapeutic use
Methenamine / analogs & derivatives,  therapeutic use
Nitrofurantoin / adverse effects,  therapeutic use
Placebos / therapeutic use
Trimethoprim / therapeutic use
Urinary Tract Infections / drug therapy,  prevention & control*
Reg. No./Substance:
0/Hippurates; 0/Placebos; 100-97-0/Methenamine; 5714-73-8/methenamine hippurate; 67-20-9/Nitrofurantoin; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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